PMID: 9546417Apr 18, 1998Paper

Pentoxifylline as an ancillary treatment for severe falciparum malaria in Thailand

The American Journal of Tropical Medicine and Hygiene
S LooareesuwanW H Wernsdorfer

Abstract

Pentoxifylline, an inhibitor of tumor necrosis factor, has been evaluated as an antimalarial agent in combination with artesunate in 45 patients with severe falciparum malaria. Patients were admitted to the intensive care unit at the Hospital for Tropical Diseases in Bangkok, Thailand, and randomly assigned to treatment for 72 hr with a combination of intravenously administered artesunate and 1) placebo, 2) low-dose pentoxifylline (0.83 mg/kg/hr), or 3) high-dose pentoxifylline (1.67 mg/kg/hr). All 45 patients had one or more manifestations of severe malaria such as cerebral malaria (n = 18), renal failure requiring hemodialysis (n = 9), azotemia (n = 8), jaundice (n = 25), or hyperparasitemia (n = 30). The overall severity was comparable in the three groups. Clinical outcome was assessed with respect to the parasite clearance time and the fever clearance time in all patients. In addition, a number of subsidiary outcome variables were examined in specific subgroups, including the recovery time from coma for patients with cerebral malaria, the duration of intubation in patients with respiratory distress, the number of hemodialysis treatments needed for patients with acute renal failure, and the number of units of blood administe...Continue Reading

Citations

Jul 19, 2003·Tropical Medicine & International Health : TM & IH·B K DasB Ravindran
Nov 15, 2006·Journal of Clinical Pharmacology·Johanna P Daily
Oct 13, 2009·Journal of Gastroenterology and Hepatology·Sombat TreeprasertsukPolrat Wilairatana
Mar 6, 2003·CNS Drugs·Neema MturiCharles R J C Newton
Oct 21, 2004·The Cochrane Database of Systematic Reviews·N AdhikariM O Meade
Oct 18, 2014·Nature Reviews. Immunology·Ricardo T GazzinelliDouglas T Golenbock
Sep 19, 2017·Journal of Clinical Apheresis·Tsong-Yih OuChung-Yi Cheng
Dec 21, 2000·Parasite Immunology·D MazierM Idrissa-Boubou
Apr 7, 2009·Nature Reviews. Neurology·Saroj K Mishra, Charles R J C Newton
Feb 26, 2005·Infection and Immunity·Christoph Josef HemmerEmil Christian Reisinger
Sep 13, 2011·Expert Review of Anti-infective Therapy·Sarah J HigginsW Conrad Liles
Dec 24, 2010·Malaria Journal·Bertrand LellCharles R J C Newton
Sep 8, 2010·Expert Review of Anti-infective Therapy·Chandy C JohnRobert O Opoka
Jan 25, 2018·Malaria Journal·Rosauro VaroQuique Bassat
Dec 21, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Sha HuangJongyoon Han
Mar 12, 1999·Annual Review of Medicine·P Newton, N White
Mar 24, 2004·International Journal for Parasitology·Katja BeckerHagai Ginsburg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.