PMID: 8956977Nov 1, 1996Paper

Pentoxifylline delays the onset of experimental allergic encephalomyelitis in mice by modulating cytokine production in peripheral blood mononuclear cells

Immunopharmacology
Y OkudaT Yanagihara

Abstract

The effect of pentoxifylline (PTX) on experimental allergic encephalomyelitis (EAE) in mice, a known animal model of multiple sclerosis (MS), was investigated. PTX was orally administrated at 10, 40 and 100 mg/kg/day, respectively. Although oral PTX at these doses had no significant effect on the incidence and severity of EAE, oral PTX (40 mg/kg/day) alone produced a significant delay in the onset of EAE. Semiquantitative reverse transcriptase-polymerase chain reaction analysis revealed that PTX at this dose reduced the mRNA levels for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 in peripheral blood mononuclear cells (PBMC) of mice with EAE. A histopathological study showed that PTX treatment delayed infiltration of inflammatory cells in the central nervous system (CNS) of mice with EAE. These results indicated that the tolerable dose of PTX had a suppressive effect on the induction phase of EAE by modulating cytokine production in PBMC but had no effect on the severity of EAE. The findings in the present study with animals suggested that a tolerable dose of PTX might prolong the intervals between relapses in MS, but might not improve the clinical sign and symptoms of MS.

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Citations

Nov 25, 2005·Bulletin of Experimental Biology and Medicine·O T KudaevaV A Kozlov
Apr 15, 1999·Annual Review of Neuroscience·C W Olanow, W G Tatton
May 5, 2001·Expert Opinion on Pharmacotherapy·F Sánchez-Madrid, R González-Amaro
Nov 1, 1996·Journal of Child Neurology·S GuptaP D Shilling
May 5, 2001·Expert Opinion on Pharmacotherapy·A Ballinger, G Smith
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C M FlemingP W Finn
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·H Dinter

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