PMID: 8964650Dec 1, 1995Paper

Pentoxifylline exerts synergistic immunomodulatory effects in combination with dexamethasone or cyclosporin A

International Journal of Immunopharmacology
J O FunkP Zabel

Abstract

The methylxanthine derivative pentoxifylline (PTX) is an immunomodulatory agent with incompletely characterized effects on cytokine production. To analyse these effects and to delineate new combination strategies in immunotherapy, we have investigated immunomodulatory properties of PTX in combination with dexamethasone (DEX) or cyclosporin A (CsA). Stimulated human peripheral blood mononuclear cells were treated with clinically relevant concentrations of PTX (12.5-100 micrograms/ml), DEX (0.01-10 microM) or CsA (12.5-50 ng/ml), alone or in combination. With increasing doses of PTX the maximum supernatant titres of tumour necrosis factor (TNF)-alpha, interleukin (IL)-2 and interferon (IFN)-gamma decreased concomitantly, and all cultures co-treated with DEX showed synergism. Release of IL-6 was not consistently altered under PTX treatment. Similarly, PTX and CsA synergistically inhibited the release of IL-2, IFN-gamma and, to a lesser degree, TNF-alpha. Although PTX alone did not significantly reduce lymphoproliferation, both combinations of drugs synergistically inhibited this process. Furthermore, to demonstrate that the key mechanism of PTX-induced effects is an increase in intracellular cyclic adenosine 3':5'-monophosphate (c...Continue Reading

References

Apr 1, 1992·Immunology Today·S L Schreiber, G R Crabtree
Oct 1, 1992·The Journal of Infectious Diseases·C C ChaoP K Peterson
Oct 1, 1991·Immunology Today·R P PhippsR L Roper
Sep 30, 1988·Biochemical and Biophysical Research Communications·R M StrieterS L Kunkel
Jan 1, 1989·Renal Failure·L J BrunnerD R Luke
Dec 23, 1989·Lancet·P ZabelU F Schade
Feb 10, 1989·Cell·M Beato
Jan 1, 1988·Journal of Steroid Biochemistry·P M GuyreP D Manganiello
Oct 1, 1987·European Journal of Immunology·L A AardenP M Lansdorp
Aug 1, 1993·Immunology Letters·K RieneckK Bendtzen
Aug 1, 1994·European Journal of Immunology·N ReilingS Hauschildt
Jan 1, 1993·Cancer Immunology, Immunotherapy : CII·B J DezubeA B Pardee
Apr 1, 1993·Immunobiology·P ZabelM Schlaak
Jul 1, 1993·Transplantation·H TilgD Niederwieser
Jun 1, 1993·The Journal of Experimental Medicine·A L MoreiraG Kaplan

❮ Previous
Next ❯

Citations

Sep 16, 2010·Clinical Rheumatology·Iliana AlexoudiGeorge Vaiopoulos
Nov 1, 1996·International Journal of Immunopharmacology·D W HoskinA P Makrigiannis
Dec 1, 1996·International Journal of Immunopharmacology·C L D'HellencourtM Guenounou
Jan 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M WördemannW Jelkmann
Mar 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jin-Moo LeeJan Xu
Apr 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·A SinghM J Reed
Dec 21, 2006·International Immunopharmacology·Zorica Stojić VukanićM Dimitrijević
May 30, 2006·Pharmacology & Therapeutics·Waldiceu A VerriSérgio H Ferreira
Jan 1, 2005·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jan OsterreicherYvona Mazurová
Jul 4, 2001·The American Journal of Cardiology·D L Dawson
Jun 9, 1998·Respiratory Medicine·J Müller-Quernheim
Jan 13, 2018·International Journal of Molecular Sciences·Grzegorz WystrychowskiAntoni Wystrychowski
Apr 25, 2003·Vascular Medicine·Steven M Dean
Dec 17, 2009·Expert Opinion on Therapeutic Targets·Sabina A Antoniu
Oct 18, 2019·Veterinary Medicine and Science·Evangel KummariTodd Archer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.