Pentoxifylline for treatment of sepsis and necrotizing enterocolitis in neonates

The Cochrane Database of Systematic Reviews
Mohan Pammi, Khalid N Haque

Abstract

Mortality and morbidity due to neonatal sepsis and necrotizing enterocolitis (NEC) remain high despite the use of potent antimicrobial agents. Agents that modulate inflammation may improve outcomes. Pentoxifylline, a phosphodiesterase inhibitor, is one such agent. Our primary objectives were :1.To assess the effect of intravenous pentoxifylline as an adjunct to antibiotic therapy on mortality and morbidity in neonates with suspected or confirmed sepsis.2.To assess the effect of intravenous pentoxifylline as an adjunct to antibiotic therapy on mortality and morbidity in neonates with NEC. We searched the Cochrane Neonatal Review Group Specialized Register, CENTRAL (The Cochrane Library Issue 2, 2014), EMBASE (January 1980 to May 2014), PubMed (January 1966 to May 2014), CINAHL (January 1982 to May 2014), Science Citation Index (January 1990 to May 2014), and BIOSIS (January 1992 May 2014) in May 2014. We checked references and cross-references from identified studies. We handsearched abstracts from the proceedings of the Pediatric Academic Societies Meetings (from January 1990 to May 2014). We placed no restrictions on language. We included randomised or quasi-randomised trials assessing the efficacy of pentoxifylline as an adju...Continue Reading

Associated Clinical Trials

References

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Citations

Feb 7, 2018·Frontiers in Pediatrics·Yogen SinghFarha Vora
Nov 7, 2019·Pediatric Research·Maria Giulia ContiOfer Levy
Dec 11, 2019·Antimicrobial Agents and Chemotherapy·Jacqueline C Y LaiCarina Mallard
Feb 24, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S M RanchhodJ M Dean
Dec 25, 2019·Archives of Disease in Childhood·Anna L CampbellKevin T Batty
Nov 26, 2018·Archives of Disease in Childhood·S M D K Ganga SenarathnaKevin T Batty
Mar 18, 2020·European Journal of Pediatrics·Serife KurulH Rob Taal
Jun 22, 2018·The Cochrane Database of Systematic Reviews·Emily ShepherdCaroline A Crowther
Sep 4, 2018·Oxidative Medicine and Cellular Longevity·Chiara Poggi, Carlo Dani
Aug 2, 2017·Neural Regeneration Research·Aparna PatraPeter J Giannone
Aug 4, 2018·Frontiers in Pediatrics·Simone S SchüllerOfer Levy
Mar 7, 2021·International Journal of Molecular Sciences·Daniela Mokra, Juraj Mokry

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