PMID: 8607655Apr 1, 1996Paper

Pentoxifylline in flush solution improves early lung allograft function

The Annals of Thoracic Surgery
M YamashitaG A Patterson

Abstract

Postischemic ischemia reperfusion injury is a frequent and unpredictable problem in clinical lung transplantation. Pentoxifylline (PTX) has a number of effects that could decrease reperfusion injury: reduced neutrophil adhesion to endothelium, decreased production of tumor necrosis factor, decreased platelet aggregation, and increased production of vasodilatory prostaglandins by vascular endothelium. We have demonstrated previously that PTX administered before storage and again during reperfusion reduced lung reperfusion injury. The purpose of the present study was to determine whether these observations were storage or reperfusion effects. Fourteen canine left lung allotransplantations were performed. Donor lungs were flushed with modified Euro-Collins solution and stored for 24 hours at 1 degree C. Immediately after transplantation, the contralateral right main pulmonary artery and bronchus were ligated to assess isolated allograft function. Hemodynamic indices and arterial blood gas analysis (inspired oxygen fraction 1.0) were assessed for 6 hours before sacrifice. Allograft myeloperoxidase activity was assessed. Bronchoalveolar lavage fluid was obtained from the allograft middle lobe for neutrophil counts. The animals were ...Continue Reading

References

Dec 1, 1991·The American Review of Respiratory Disease·R J McDonald
Nov 1, 1991·Journal of Cardiovascular Pharmacology·G BerkenboomJ Fontaine
May 1, 1990·Transplantation·K L Berens, D R Luke
Nov 1, 1988·The American Review of Respiratory Disease·G L Mandell
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Oct 1, 1994·Journal of Cardiovascular Pharmacology·J KamphuisT Thien
Jul 1, 1994·The Annals of Thoracic Surgery·K OkabayashiG A Patterson
Jun 1, 1993·The Annals of Thoracic Surgery·T M EganB R Wilcox
Nov 1, 1995·The Annals of Thoracic Surgery·M HaniudaG A Patterson

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Citations

Dec 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Stephen C ClarkJohn H Dark
Feb 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·S C ClarkJ H Dark
May 10, 2003·American Journal of Respiratory and Critical Care Medicine·Makoto SugitaYves Berthiaume
Sep 1, 2005·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Andreas Pascher, Jochen Klupp
Jun 17, 1998·The Journal of Thoracic and Cardiovascular Surgery·S C ClarkJ H Dark
Apr 24, 1999·The Annals of Thoracic Surgery·R L FeatherstoneD J Chambers
Dec 22, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·R L FeatherstoneD J Chambers

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