Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity

Vaccine
Alberto MantovaniBarbara Bottazzi

Abstract

Pentraxin 3 (PTX3) is the first long pentraxin identified. Long pentraxins consist of a C-terminal pentraxin domain, which has sequence similarity to C-reactive protein (CRP) and serum amyloid P (SAP) component (the classic short pentraxins), and of an unrelated N-terminal portion. PTX3 is made by diverse cell types, most prominently endothelial cells, macrophages and dendritic cells, in response to primary inflammatory signals (e.g. interleukin-1 (IL-1), tumour necrosis factor (TNF), lipopolysaccharide (LPS)). It binds diverse ligands, including microbial moieties, C1q and apoptotic cells. Evidence suggests that PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.

References

Oct 1, 1986·Molecular Immunology·C L Bristow, R J Boackle
Oct 14, 1987·Biochemical and Biophysical Research Communications·M B Pepys, P J Butler
Oct 1, 1981·The Journal of Experimental Medicine·F C de BeerM B Pepys
Jan 1, 1982·Annals of the New York Academy of Sciences·J E Volanakis
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
Nov 10, 1995·The Journal of Biological Chemistry·P García de FrutosB Dahlbäck
Sep 22, 1993·Proceedings. Biological Sciences·L T SeeryA S Whitehead
Jan 27, 1994·Nature·J EmsleyS P Wood
Aug 1, 1996·Cytokine & Growth Factor Reviews·A R GoodmanJ Vilcek
Apr 1, 1998·European Journal of Immunology·N PolentaruttiM Introna
Dec 22, 1999·Clinical and Experimental Immunology·M M LuchettiA Gabrielli
Mar 25, 2000·Journal of Leukocyte Biology·A R GoodmanJ Vilcek
May 18, 2000·Journal of Neuroimmunology·N PolentaruttiA Mantovani
Sep 21, 2000·European Journal of Haematology·L MalaguarneraA Messina

❮ Previous
Next ❯

Citations

Nov 19, 2008·Clinical Reviews in Allergy & Immunology·N BassiA Doria
Apr 28, 2004·Cytokine & Growth Factor Reviews·Hans-Georg Wisniewski, Jan Vilcek
Nov 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Marco Colonna
Nov 17, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ruth DubinCarmen A Peralta
Apr 20, 2011·Pathology International·Alexander S SavchenkoMakoto Naito
Mar 18, 2005·Annual Review of Immunology·Cecilia GarlandaAlberto Mantovani
Feb 22, 2012·International Journal of Vascular Medicine·Kenji InoueHiroyuki Daida
Jul 24, 2012·American Journal of Respiratory and Critical Care Medicine·Joshua M DiamondUNKNOWN Lung Transplant Outcomes Group
Nov 19, 2008·BMC Gastroenterology·Masato YonedaAtsushi Nakajima
Oct 2, 2009·Journal of Perinatal Medicine·Laura CrucianiGian Carlo Di Renzo
Jul 5, 2006·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Daisuke Okutani
Nov 22, 2012·European Journal of Gastroenterology & Hepatology·Darren G CraigKenneth James Simpson
Sep 5, 2006·Nature Clinical Practice. Rheumatology·Martine Szyper Kravitz, Yehuda Shoenfeld
Dec 18, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maciej LechHans-Joachim Anders
Feb 14, 2016·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Wen-Chien FanHan-Chieh Lin
Oct 8, 2008·Annals of the New York Academy of Sciences·Michael Ellis
Oct 7, 2006·Vascular Pharmacology·Alberto MantovaniRoberto Latini
Mar 17, 2016·Expert Review of Clinical Immunology·Patrick KetterBernard Arulanandam
Jun 25, 2005·Journal of Medical Virology·Albert T A MairuhuEric C M van Gorp
May 16, 2015·Stem Cells and Development·Mino KangMinYoung Kim
Sep 1, 2007·Journal of Cellular and Molecular Medicine·Marco PrestaMarco Rusnati
Jan 29, 2008·The Journal of Pathology·As SavchenkoM Naito
Mar 3, 2015·Frontiers in Immunology·Eridan Rocha-Ferreira, Mariya Hristova
Jul 11, 2008·Seminars in Arthritis and Rheumatism·Oscar-Danilo Ortega-HernandezJuan-Manuel Anaya
Jun 1, 2007·Biology of Reproduction·Susanne TranguchSudhansu K Dey
Sep 25, 2004·Immunology Letters·Uday KishoreAlok Agrawal
Oct 15, 2014·Journal of Clinical Immunology·Esmaeil MortazPeter J Barnes
Dec 31, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maj HedtjärnHenrik Hagberg
Mar 14, 2018·International Journal of Radiation Biology·Tünde SzatmáriKatalin Lumniczky
Jul 9, 2014·Infection and Immunity·Patrick M KetterBernard P Arulanandam
Jul 16, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Maura CamozziMarco Presta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.