Pentraxin 3: a novel biomarker for inflammatory cardiovascular disease.

International Journal of Vascular Medicine
Kenji InoueHiroyuki Daida

Abstract

Numerous studies have recently examined the role of pentraxin 3 (PTX3) in clinical situations. The pentraxin family includes C-reactive protein (CRP); however, unlike CRP, PTX3 is expressed predominantly in atherosclerotic lesions that involve macrophages, neutrophils, dendritic cells, or smooth muscle cells. Interestingly, PTX3 gene expression in human endothelial cells is suppressed to a greater extent by pitavastatin than the expression of 6,000 other human genes that have been examined, suggesting that PTX3 may be a novel biomarker for inflammatory cardiovascular disease. The expression and involvement of PTX3 in cardiovascular diseases are discussed in this paper, along with the characteristics of PTX3 that make it a suitable biomarker; namely, that the physiological concentration is known and it is independent of other risk factors. The results discussed in this paper suggest that further investigations into the potential novel use of PTX3 as a biomarker for inflammatory cardiovascular disease should be undertaken.

References

Dec 22, 1999·Clinical and Experimental Immunology·M M LuchettiA Gabrielli
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akira YamashinaYoshio Yamamoto
Sep 30, 2003·European Journal of Immunology·Andrea DoniAlberto Mantovani
May 22, 2004·Journal of Atherosclerosis and Thrombosis·Shigeru MorikawaTatsuhiko Kodama
Oct 13, 2004·Circulation·Roberto LatiniUNKNOWN Lipid Assessment Trial Italian Network (LATIN) Investigators
Mar 18, 2005·Annual Review of Immunology·Cecilia GarlandaAlberto Mantovani
Feb 16, 2006·Journal of Leukocyte Biology·Barbara BottazziAlberto Mantovani
Nov 11, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Kenji InoueTatsuhiko Kodama
Mar 29, 2007·The Journal of Experimental Medicine·Sébastien JaillonAlberto Mantovani
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Mengli TongMohamed E Suliman
Nov 9, 2007·Digestive Diseases and Sciences·Shingo KatoKoji Yakabi
Dec 29, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Cindy GustinMartine Raes
Jan 29, 2008·The Journal of Biological Chemistry·Antonio InforzatoGiovanni Salvatori
Feb 13, 2008·Circulation·Monica SalioAlberto Mantovani
Jul 4, 2008·Critical Care Medicine·Tommaso MauriAntonio Pesenti
Mar 11, 2009·The Journal of Rheumatology·Yohei IwataShinichi Sato
Mar 31, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Kazumi YamasakiKenji Inoue
Aug 12, 2009·Circulation·Giuseppe Danilo NorataAlberico Luigi Catapano
Dec 1, 2009·Atherosclerosis·Shigeru MatsuiYukio Ozaki
Mar 9, 2010·Nature Immunology·Livija DebanAlberto Mantovani
Oct 12, 2010·American Heart Journal·Yoshiro NaitoTohru Masuyama
Jan 5, 2011·American Journal of Hypertension·Takatoshi KasaiKoji Narui
Feb 19, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Mahmut Ilker YilmazJuan Jesús Carrero
Apr 20, 2011·Pathology International·Alexander S SavchenkoMakoto Naito
Jun 17, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Norma MaugeriAngelo A Manfredi

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Citations

Sep 12, 2012·International Urology and Nephrology·Usama ElewaAlberto Ortiz
Mar 6, 2016·Journal of Neuroimmunology·Ivana RajkovicEmmanuel Pinteaux
Sep 29, 2015·Journal of Atherosclerosis and Thrombosis·Yoshihiro KomoharaMotohiro Takeya
Jan 5, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Savas OzsuJosé M Porcel
May 6, 2014·Immunology Letters·Kenji DaigoBarbara Bottazzi
Sep 15, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Claudio PassinoAldo Clerico
Aug 28, 2016·The American Journal of Emergency Medicine·Ahmet BaydinSabri Demircan
Jul 19, 2016·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Aziza Ahmed El SebaiEngy Yousry El Sayed
Aug 26, 2016·Immunity & Ageing : I & a·Francesco FornaiCarmine Vecchione
Nov 14, 2016·Clinical Biochemistry·Roya FarhadiJamshid Yazdani
Sep 30, 2017·The Clinical Respiratory Journal·Volkan SozerHafize Uzun
Apr 14, 2018·Journal of the American Heart Association·Abraham AbernethyMartin M LeWinter
Jan 14, 2020·Biomedical Reports·Gang-Yong WuXiang-Jun Yang
Jul 29, 2020·Reviews in Medical Virology·Ninaad Lasrado, Jay Reddy
Apr 5, 2020·Journal of Clinical Medicine·Clara Domínguez-ViveroRogelio Leira
Dec 14, 2016·International Journal of Endocrinology·S BurlinaA Lapolla
Sep 24, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Martina ZaninottoMario Plebani

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Methods Mentioned

BETA
chip
transgenic
FACS
confocal microscopy

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