Pentraxin 3 as a novel diagnostic marker in neonatal sepsis

Journal of Neonatal-perinatal Medicine
Sameh Samir Fahmey, N Mostafa

Abstract

Neonatal sepsis is an important cause of morbidity and mortality especially in developing countries. As clinical manifestations of neonatal sepsis are nonspecific, early diagnosis and treatment remain a challenge. Pentraxin 3 (PTX3) is an acute-phase protein secreted by various cells in response to the proinflammatory signals. Our aim was to investigate the diagnostic value of PTX3 in neonatal sepsis. We studied 90 neonates; 60 with culture-proven sepsis and 30 healthy neonates as a control group. Serum levels of PTX 3 were measured by ELISA. Neonates with sepsis had significantly higher levels of PTX 3 as compared to controls (p < 0.001). Diagnostic cutoff value of PTX 3 was 5.6 μg/L with a sensitivity of 98.3% and a specificity of 96.7%. PTX 3 was significantly increased in nonsurvivors when compared to survivors (p < 0.001). PTX3 had better sensitivity when compared with CRP. PTX 3 could be used as a new biomarker of neonatal sepsis with high sensitivity and specificity.

References

Apr 6, 2002·Clinics in Laboratory Medicine·P Joanne Cornbleet
Sep 11, 2007·Journal of Clinical Immunology·Alberto MantovaniBarbara Bottazzi
Dec 8, 2009·The Journal of Infection·Martijn D de KruifEric C M van Gorp
Feb 11, 2010·Critical Care : the Official Journal of the Critical Care Forum·Charalampos Pierrakos, Jean-Louis Vincent
Nov 5, 2013·Virulence·Birju A Shah, James F Padbury
Jul 23, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mustafa Ali AkinSelim Kurtoglu
Sep 13, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S Basu
Dec 23, 2014·Mediators of Inflammation·Siguan LiuChunting Wang
Mar 26, 2015·The Pediatric Infectious Disease Journal·Christina W ObieroJames A Berkley
Jan 12, 2016·Pediatrics and Neonatology·Francesca CorteseMarco Matteo Ciccone
Nov 20, 2016·European Journal of Clinical Investigation·Pietro CaironiUNKNOWN ALBIOS Biomarkers Study Investigators
Apr 22, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Deepak SharmaPradeep Sharma
Apr 25, 2017·Lancet·Andi L ShaneBarbara J Stoll
Jun 21, 2017·Antimicrobial Resistance and Infection Control·Lamiaa MohsenHany Aly
Oct 5, 2017·PloS One·Isabelle M C ReeEnrico Lopriore
Feb 25, 2018·European Journal of Pediatrics·Ioannis BellosGeorgios Daskalakis
Jun 11, 2018·Journal of Critical Care·Fady M El GendyFaten Ezzelarab Younis

❮ Previous
Next ❯

Citations

Apr 5, 2020·Journal of Clinical Medicine·Clara Domínguez-ViveroRogelio Leira
Nov 4, 2021·Pediatric Research·Istemi Han Celik Mohan Pammi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.