Pentraxin 3 Induces Vascular Endothelial Dysfunction Through a P-selectin/Matrix Metalloproteinase-1 Pathway

Circulation
Albino CarrizzoCarmine Vecchione

Abstract

Pentraxin 3 (PTX3), the prototype of long pentraxins, has been described to be associated with endothelial dysfunction in different cardiovascular disorders. No study has yet evaluated the possible direct effect of PTX3 on vascular function. Through in vitro experiments of vascular reactivity and ultrastructural analyses, we demonstrate that PTX3 induces dysfunction and morphological changes in the endothelial layer through a P-selectin/matrix metalloproteinase-1 pathway. The latter hampered the detachment of endothelial nitric oxide synthase from caveolin-1, leading to an impairment of nitric oxide signaling. In vivo studies showed that administering PTX3 to wild-type mice induced endothelial dysfunction and increased blood pressure, an effect absent in P-selectin-deficient mice. In isolated human umbilical vein endothelial cells, PTX3 significantly blunted nitric oxide production through the matrix metalloproteinase-1 pathway. Finally, using ELISA, we found that hypertensive patients (n=31) have higher plasma levels of PTX3 and its mediators P-selectin and matrix metalloproteinase-1 than normotensive subjects (n=21). Our data show for the first time a direct role of PTX3 on vascular function and blood pressure homeostasis, id...Continue Reading

References

Apr 23, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Nalini M RajamannanStephen W Carmichael
May 16, 2002·Molecular Immunology·Vladimír HolánJana Pindjáková
Nov 8, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Richard D MinshallAsrar B Malik
Dec 9, 2003·European Heart Journal·Andrew D BlannGregory Y H Lip
Oct 12, 2004·The International Journal of Biochemistry & Cell Biology·Annie Pardo, Moisés Selman
Mar 18, 2005·Annual Review of Immunology·Cecilia GarlandaAlberto Mantovani
Jul 12, 2005·Diabetes Research and Clinical Practice·Seung Won LeeKwan-Woo Lee
Apr 6, 2006·Circulation·Ulrich Förstermann, Thomas Münzel
Sep 1, 2007·Journal of Cellular and Molecular Medicine·Marco PrestaMarco Rusnati
Mar 29, 2008·The Biochemical Journal·John M HarringtonPeter B Armstrong
Apr 18, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Mohamed E SulimanPeter Stenvinkel
Mar 17, 2009·The American Journal of Pathology·Danielle G SouzaMauro M Teixeira
Mar 9, 2010·Nature Immunology·Livija DebanAlberto Mantovani
Jul 27, 2010·Trends in Cardiovascular Medicine·Giuseppe Danilo NorataAlberico Luigi Catapano
Jul 1, 2011·Journal of Biomedicine & Biotechnology·Federica MoalliCecilia Garlanda
Jul 15, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Rangeen Rafik HamadKatarina Bremme
Sep 29, 2011·Advances in Experimental Medicine and Biology·Antonio InforzatoAlberto Mantovani
Apr 3, 2012·Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology·Adem ParlakKenan Sağlam
Nov 17, 2012·Immunity & Ageing : I & a·Annibale Alessandro PucaCarmine Vecchione
Mar 27, 2013·Annals of the New York Academy of Sciences·Alberto MantovaniCecilia Garlanda
Apr 26, 2013·Journal of Hypertension·Pedro MorillasVicente Bertomeu-Martínez
Oct 12, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Hongfei ZhuJinjie Li

❮ Previous
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Citations

Dec 4, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Francesca SantilliGiovanni Davì
Oct 21, 2015·The International Journal of Biochemistry & Cell Biology·Francesco FornaiCarmine Vecchione
May 13, 2015·Vascular Pharmacology·Gemma Vilahur, Lina Badimon
May 18, 2016·Trends in Molecular Medicine·Elena MagriniCecilia Garlanda
Aug 26, 2016·Immunity & Ageing : I & a·Francesco FornaiCarmine Vecchione
Oct 27, 2016·Immunological Reviews·Kenji DaigoAlberto Mantovani
Nov 20, 2016·European Journal of Clinical Investigation·Pietro CaironiUNKNOWN ALBIOS Biomarkers Study Investigators
Feb 8, 2018·Physiological Reviews·Cecilia GarlandaAlberto Mantovani
Nov 14, 2017·European Journal of Clinical Investigation·Federico CarboneFabio Rigamonti
Apr 28, 2018·The Journal of Clinical Hypertension·Jia-Wen HuJian-Jun Mu
Oct 4, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Martin J Wolley, Colin A Hutchison
Nov 10, 2018·Journal of Clinical Laboratory Analysis·Çağlar AlpÜçler Kısa
Jul 30, 2019·Frontiers in Immunology·Thiago Henrique Caldeira de OliveiraFlávio Almeida Amaral
Nov 14, 2016·Molecular and Cellular Biochemistry·Eman A E BadrElsayed I Elshayeb
Jan 26, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Hong ZhuDalong Zhu
Mar 16, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Eline L VegterAdriaan A Voors
May 26, 2017·Frontiers in Immunology·Sofia PavanelloPiera Boschetto
May 31, 2019·Frontiers in Immunology·Stefano GambardellaFrancesco Fornai
Jun 9, 2020·Frontiers in Physiology·Andrea FariniYvan Torrente
May 29, 2016·Molecular Nutrition & Food Research·Albino CarrizzoCarmine Vecchione
Apr 25, 2017·Therapeutic Hypothermia and Temperature Management·Moman A MohammadDavid Erlinge
Mar 7, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Martin WolleyColin A Hutchison
Nov 21, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yun Liu, Ping Li
Nov 21, 2019·International Journal of Molecular Sciences·Yeon KimMoon-Kyoung Bae
Feb 9, 2019·Immunity & Ageing : I & a·Albino CarrizzoCarmine Vecchione
Sep 18, 2020·Respiratory Research·Pengfei GaoJungang Xie
Nov 11, 2019·Molecular Genetics and Metabolism·Daniel A Jaramillo-CalleHerbert L Bonkovsky
Mar 6, 2021·Frontiers in Immunology·Benoit BrillandYves Delneste
Oct 21, 2017·Vascular Pharmacology·Matteo CasulaFederico Carbone
Jun 25, 2021·Journal of Molecular and Cellular Cardiology·Cierra J WalkerLeslie A Leinwand
Apr 23, 2020·Current Vascular Pharmacology·Sevket Balta
Dec 1, 2021·Stroke; a Journal of Cerebral Circulation·Chien-Heng LinSyuan-Yu Hong

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