Pentraxin levels in non-eosinophilic versus eosinophilic asthma.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Pengfei GaoJungang Xie

Abstract

Innate immunity has been thought to be involved in asthma pathogenesis. Pentraxins, acting as soluble pattern recognition molecules, play an important role in humoral innate immunity. Asthma is a heterogeneous inflammatory disease of airways and can be classified as eosinophilic or non-eosinophilic asthma. To investigate whether pentraxin levels differ in subjects with eosinophilic versus non-eosinophilic asthma. Furthermore, to access the predictive performance of pentraxin levels for discriminating asthma inflammatory phenotypes. A total of 80 asthmatic patients and 24 healthy control subjects underwent sputum induction at study inclusion. Differential leucocyte counts were performed on selected sputum. Plasma C-reactive protein (CRP), serum amyloid P (SAP), pentraxin 3 (PTX3), and sputum SAP, PTX3, IL-8 levels were determined by enzyme-linked immunosorbent assay. Subjects with non-eosinophilic asthma had significantly increased pentraxin levels compared with those with eosinophilic asthma and healthy controls, with median (interquartile range) plasma CRP levels of 0.86 (0.28-2.07), 0.26 (0.14-0.85), and 0.15 (0.09-0.45)mg/L (P < .001), respectively, plasma SAP levels of 33.69 (19.79-58.39), 19.76 (16.11-30.58), and 20.06 (15...Continue Reading

References

Jan 1, 1994·Clinical Immunology and Immunopathology·T W Du ClosC Mold
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·M NoursadeghiM B Pepys
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander J SzalaiScott R Barnum
Oct 24, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Pekka JousilahtiTimo Palosuo
Jan 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jodie L SimpsonPeter G Gibson
May 19, 2006·The European Respiratory Journal·M TakemuraM Mishima
Jul 18, 2006·Thorax·Jodie L SimpsonPeter G Gibson
Mar 29, 2007·The Journal of Experimental Medicine·Sébastien JaillonAlberto Mantovani
May 3, 2007·The Journal of Allergy and Clinical Immunology·Pranab Haldar, Ian D Pavord
Jan 2, 2008·The European Respiratory Journal·E D BatemanH J Zar
Oct 3, 2009·The European Respiratory Journal·K J BainesP G Gibson
Oct 10, 2009·Respiration; International Review of Thoracic Diseases·Jodie L SimpsonPeter G Gibson
Mar 9, 2010·Nature Immunology·Livija DebanAlberto Mantovani
Jun 24, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Daniel RamirezSami L Bahna
Aug 3, 2010·The Journal of Allergy and Clinical Immunology·Ana Paula MoreiraCory M Hogaboam
Aug 5, 2010·Cell and Tissue Research·Livija DebanAlberto Mantovani
Jul 1, 2011·Journal of Biomedicine & Biotechnology·Federica MoalliCecilia Garlanda
Jan 24, 2012·American Journal of Respiratory and Critical Care Medicine·Kelly Wong McGrathUNKNOWN Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute
May 9, 2012·Nature Medicine·Stephen T Holgate
Jan 18, 2013·Kidney International·Maciej LechHans-Joachim Anders
May 16, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Makoto HoshinoKenta Akitsu
May 24, 2014·The International Journal of Biochemistry & Cell Biology·Marianna AgassandianMichael R Shurin
Feb 26, 2015·Allergy and Asthma Proceedings·Terufumi ShimodaTomoaki Iwanaga
May 13, 2015·Vascular Pharmacology·Gemma Vilahur, Lina Badimon
Feb 28, 2016·Journal of Hepatology·Barbara BottazziAlberto Mantovani
Mar 2, 2016·Therapeutic Advances in Respiratory Disease·Neil C Thomson
Aug 28, 2016·The Journal of Allergy and Clinical Immunology·Jyoti BalharaAbdelilah S Gounni
Apr 20, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luis PereaPau Sancho-Bru

❮ Previous
Next ❯

Citations

Feb 7, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Amelia LicariGiorgio Ciprandi
Apr 5, 2020·European Journal of Immunology·Ursula SmoleWinfried F Pickl
Sep 18, 2020·Respiratory Research·Pengfei GaoJungang Xie
Dec 14, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Graham RobertsJ A Woodfolk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.