Pentylenetetrazole-induced status epilepticus following training does not impair expression of morphine-induced conditioned place preference

Addiction Biology
Jie ZhangYuan-Ye Ma

Abstract

Learning and memory play an important role in morphine addiction. Status epilepticus (SE) can impair the spatial and emotional learning and memory. However, little is known about the effects of SE on morphine-induced conditioned place preference (CPP). The present study was designed to investigate the effects of SE on morphine CPP, with food CPP being used as a control. The effects of SE on spatial memory in the Morris water maze (MWM) and Y-maze were investigated. SE was induced in adult mice using intraperitoneal injection of pentylenetetrazole; control mice received saline. The data indicated that SE had no effects on the formation of morphine CPP; however, the formation of food CPP was blocked by SE. Meanwhile, spatial memory assayed in the MWM and Y-maze was impaired by SE. In addition, the data demonstrated that SE did not cause a lasting disturbance of motor activity nor a change in the mice's appetite. These results suggested that although SE had no effects on morphine CPP, there was impaired food CPP and spatial memory in both the MWM and the Y-maze. The mechanisms underlying memory process of morphine CPP may be different from other types of memory.

References

Jul 1, 1977·Pharmacology, Biochemistry, and Behavior·H B Bookin, W D Pfeifer
Dec 20, 1993·Behavioural Brain Research·C TomazF G Graeff
Mar 28, 1996·European Journal of Pharmacology·T HalonenA Pitkänen
Jan 15, 2000·Science·J L McGaugh
Jun 26, 2001·Science·E J Nestler
Aug 4, 2001·Methods and Findings in Experimental and Clinical Pharmacology·S BalakrishnanP Pandhi
Aug 31, 2002·Phytotherapy Research : PTR·Veena S KastureC T Chopde
Oct 3, 2003·Neurobiology of Learning and Memory·Ann E PowerJames L McGaugh
Mar 29, 2005·Nature Neuroscience·Christelle BaunezMarianne Amalric
Aug 13, 2005·Experimental Brain Research·Axel BeckerGisela Grecksch
Oct 28, 2005·Nature Neuroscience·Yavin Shaham, Bruce T Hope
Oct 28, 2005·Nature Neuroscience·Peter W Kalivas
Mar 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·K TouzaniE R Kandel

❮ Previous
Next ❯

Citations

Feb 22, 2012·Zoological Research·Xu-Jun WuJian-Hong Wang
Sep 30, 2010·Peptides·Richard J Bodnar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.