People with schizophrenia show enhanced cognitive costs of maintaining a single item in working memory.

Psychological Medicine
James M GoldSteven J Luck

Abstract

Working memory (WM) deficits are seen as a core deficit in schizophrenia, implicated in the broad cognitive impairment seen in the illness. Here we examine the impact of WM storage of a single item on the operation of other cognitive systems. We studied 37 healthy controls (HCS) and 43 people with schizophrenia (PSZ). Each trial consisted of a sequence of two potential target stimuli, T1 and T2. T1 was a letter presented for 100 ms. After delays of 100-800 ms, T2 was presented. T2 was a 1 or a 2 and required a speeded response. In one condition, subjects were instructed to ignore T1 but respond to T2. In another condition, they were required to report T1 after making their speeded response to T2 (i.e. to make a speeded T2 response while holding T1 in WM). PSZ were dramatically slowed at responding to T2 when T1 was held in WM. A repeated measures ANOVA yielded main effects of group, delay, and condition with a group by condition interaction (p's < 0.001). Across delays, the slowing of the T2 response when required to hold T1 in memory, relative to ignoring T1, was nearly 3 times higher in PSZ than HCS (633 v. 219 ms). Whereas previous studies have focused on reduced storage capacity, the present study found that PSZ are impaire...Continue Reading

References

Jan 1, 1978·Journal of Psychiatric Research·L J Chapman, J P Chapman
Sep 1, 1994·Psychological Bulletin·H Pashler
Mar 6, 1984·Social Work Research & Abstracts·L C Schneider, E L Struening
Oct 8, 1999·Journal of Experimental Psychology. General·Randall W EngleAndrew R A Conway
Aug 6, 2000·Neuropsychology·N MeiranA Henik
Jun 30, 2001·The American Journal of Psychiatry·W M PerlsteinJ D Cohen
Mar 18, 2003·Trends in Cognitive Sciences·Stephen Monsell
May 9, 2007·Experimental Brain Research·Cathleen GreenzangJason J S Barton
Sep 7, 2007·Schizophrenia Research·Johanna C BadcockAssen Jablensky
Jan 4, 2008·The American Journal of Psychiatry·Keith H NuechterleinStephen R Marder
Sep 8, 2009·Schizophrenia Research·Susan M RavizzaCameron S Carter
Nov 26, 2009·Attention, Perception & Psychophysics·Paul E Dux, René Marois
Apr 3, 2010·The American Journal of Psychiatry·David M GardnerRoss J Baldessarini
May 10, 2011·Journal of Psychiatric Research·Kristopher I MathisMichael F Green
Oct 4, 2011·Annual Review of Psychology·Alan Baddeley
Jun 5, 2012·Cerebral Cortex·Carly J LeonardSteven J Luck
Feb 5, 2013·The American Journal of Psychiatry·Ann M KringSteven P Reise
Jul 16, 2013·Trends in Cognitive Sciences·Steven J Luck, Edward K Vogel
Aug 5, 2014·Journal of Abnormal Psychology·Steven J LuckJames M Gold
Jun 9, 2015·Trends in Cognitive Sciences·Mark G Stokes
Jan 12, 2017·Schizophrenia Research·Britta HahnElliot A Stein
Mar 12, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Johanna KreitherSteven J Luck
Aug 15, 2018·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Britta HahnJames M Gold

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