Peperomin E (PepE) protects against high fat diet-induced atherosclerosis in Apolipoprotein E deficient (ApoE-/- ) mice through reducing inflammation via the suppression of NLRP3 signaling pathway

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Jin YanXiao-Long Ni

Abstract

Peperomin E (PepE) is a type of secolignan, a major component of the plant Peperomia dindygulensis. It has been shown to exert anti-inflammatory effects; however, the effects of PepE on human atherosclerosis remain unexplored. In the study, we investigated the role of PepE in high fat diet (HFD) induced atherosclerosis using apolipoprotein E defcient (ApoE-/-) mice. Elevated serum homocyteine, cholesterol, and triglyceride levels, accelerated progression of atherosclerosis and exacerbated macrophage infiltration into atherosclerotic lesions were observed in HFD-fed ApoE-/- mice, which were attenuated by PepE treatment. ApoE-/- mice fed with HFD exhibited significantly high levels of inflammation-associated regulators in artery tissues, accompanied with an increased expression of p-inhibitor of κBα (IκBα) and p-nuclear factor-kappa B (NF-κB), and the process was blocked by PepE administration. Further, we found NOD-like receptor pyrin 3 (NLRP3) inflammasome activation in artery tissues of HFD-fed ApoE-/- mice. In vitro, silencing NLRP3 using small interfering RNA efficiently inhibited oxidized-low-density lipoprotein (oxLDL)-induced ASC and Caspase-1 expressions, interleukin (IL)-1β and IL-18 production in human aortic endotheli...Continue Reading

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Citations

Oct 14, 2018·Biotechnology and Applied Biochemistry·Takami Sho, JianXiong Xu
Jul 1, 2021·Journal of Inflammation Research·Nan JiJunping Zhang
Jul 25, 2021·International Journal of Molecular Sciences·Pengwei Li, Mingxian Chang

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