Pepsin: biomarker, mediator, and therapeutic target for reflux and aspiration

Annals of the New York Academy of Sciences
Nikki JohnstonJonathan M Bock

Abstract

Extra-esophageal reflux is suspected to cause a wide range of clinical symptoms in the upper airways. Diagnosis and treatment has focused on acid, but realization of the role of nonacid reflux has resulted in research investigating the use of pepsin as a biomarker for gastric reflux and aspiration. Pepsin analysis can complement the use of questionnaires and office-based diagnosis and lessen the dependency on invasive and expensive diagnostic tests. Furthermore, pepsin as a first-line diagnostic biomarker has been shown to improve the accuracy of reflux diagnosis. In addition to its use as a diagnostic biomarker, pepsin has been shown to cause inflammation independent of the pH of the refluxate and thus despite acid suppression therapy. Research is ongoing to develop new therapies for airway reflux that specifically target pepsin.

References

Jan 1, 1986·Annals of Surgery·T Eto, R K Tompkins
Apr 24, 2001·The American Journal of Gastroenterology·H B El-SeragD M McCarthy
Jul 2, 2002·The Quarterly Review of Biology·Joseph S Fruton
Aug 6, 2002·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·James A KoufmanGary Y Shaw
Sep 29, 2005·JAMA : the Journal of the American Medical Association·Charles N Ford
Jan 13, 2006·The American Journal of Gastroenterology·Peter C Belafsky
Aug 11, 2006·Chest·Radu TutuianDonald O Castell
Sep 14, 2006·The American Journal of Gastroenterology·John M WoEric Lentsch
Apr 10, 2007·The Laryngoscope·Nikki JohnstonJamie A Koufman
Jan 26, 2008·The Annals of Otology, Rhinology, and Laryngology·Nikki JohnstonAlbert L Merati
Mar 28, 2008·Surgical Endoscopy·Mohd IqbalR T Spychal
Aug 30, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Oliver ReichelWolfgang J Issing
Sep 16, 2008·Gastroenterology·Peter J KahrilasUNKNOWN American Gastroenterological Association
Jul 15, 2009·Current Opinion in Pharmacology·Mohamed M M Abdel-LatifDermot Kelleher
Oct 9, 2009·The Annals of Otology, Rhinology, and Laryngology·Nikki JohnstonJoel H Blumin
Oct 29, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Tina L Samuels, Nikki Johnston
Mar 23, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Paul K Y LamBenjamin C Y Wong
May 5, 2010·Cleveland Clinic Journal of Medicine·David W Barry, Michael F Vaezi
Jul 14, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael F Vaezi
Jul 20, 2010·Critical Care Medicine·Hannah WunschJeremy M Kahn
Sep 24, 2010·The Annals of Otology, Rhinology, and Laryngology·Nikki JohnstonJoel H Blumin
Jun 23, 2011·Surgical Endoscopy·Eelco WassenaarBrant Oelschlager
Aug 13, 2011·American Journal of Respiratory and Critical Care Medicine·Saad NseirMalika Balduyck
Jan 14, 2012·International Journal of Otolaryngology·Karna Dev BardhanPeter W Dettmar
May 10, 2012·The Laryngoscope·Nikki JohnstonJonathan M Bock
Dec 4, 2012·European Journal of Gastroenterology & Hepatology·Nimish B VakilAnna Rydén
Apr 3, 2013·The American Journal of Gastroenterology·David O FrancisMichael F Vaezi
Apr 19, 2013·The New England Journal of Medicine·Michael Klompas
Aug 31, 2013·JAMA Otolaryngology-- Head & Neck Surgery·Elizabeth A KellyJoseph E Kerschner
Nov 2, 2013·Therapeutic Advances in Chronic Disease·Irene MartinucciSantino Marchi
Jan 1, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Elizabeth A KellyNikki Johnston
Nov 7, 2015·The European Respiratory Journal·Vicki StrugalaAlyn H Morice

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Citations

Mar 14, 2020·Therapeutic Advances in Respiratory Disease·Tiago M Alfaro, Carlos Robalo Cordeiro
May 14, 2020·Annals of the New York Academy of Sciences·Miles J KlimaraNikki Johnston
Oct 19, 2019·World Journal of Clinical Cases·Jerome R LechienSven Saussez
Sep 2, 2020·American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses·Steven TalbertMary Lou Sole
Aug 1, 2020·Clinical and Experimental Otorhinolaryngology·Cheng-Yi YinShui-Hong Zhou
Jul 14, 2021·Journal of Voice : Official Journal of the Voice Foundation·Fuat BulutBasak Ballica
Sep 25, 2021·Oncology Reports·Dimitra P VageliBenjamin L Judson
Nov 10, 2021·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Xin XiongYingdong Jia

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