PMID: 2510330Jan 1, 1989Paper

Pepsin fibrinolysis of artificial clots made from fibrinogen concentrate and bovine thrombin: the effect of pH and epsilon aminocaproic acid

Surgical Endoscopy
G A ValenzuelaD D Stone

Abstract

Artificial clots made from fibrin glue with and without an inhibitor of fibrinolysis can be used to treat gastrointestinal bleeding. We have been unable to find descriptions of the effects of acid and pepsin upon such artificial clots. Therefore, 10(-2) mol/l epsilon aminocaproic acid was added to fibrin glue in vitro at acid concentrations of pH 1.0 and pH 5.5. Pepsin was added at 9000 U/50 ml, the expected value for fasting human subjects. There was a highly significant reduction in clot survival at pH 1.0. At pH 5.5, clot weight was also significantly decreased with pepsin, compared to control. Thus pepsin and acidity greatly affect survival of artificial clots, but the addition of epsilon aminocaproic acid did not affect clot survival.

References

Dec 1, 1975·Annals of Surgery·I M NilssonU Hedner
Oct 1, 1985·Plastic and Reconstructive Surgery·F HärtingJ P Gillissen
Apr 1, 1987·Mayo Clinic Proceedings·P M McCarthyR W Beart
May 1, 1987·The Annals of Thoracic Surgery·J W BakerS P Nolan
Aug 1, 1985·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·H Matras
Nov 1, 1985·Archives of Surgery·H B KramW C Shoemaker
Aug 1, 1982·The Thoracic and Cardiovascular Surgeon·A Stemberger, G Blümel
Jun 1, 1984·The Journal of Surgical Research·H JakobR L Replogle
Jan 1, 1983·Archives of Orthopaedic and Trauma Surgery·F AlbrechtE Zimmermann
Oct 1, 1981·European Journal of Clinical Investigation·B StenbergH I Peterson
Sep 1, 1962·Gut·I E GILLESPIE, D J BOWEN

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Citations

Sep 3, 2010·Gastroenterología y hepatología·Xavier Calvet
Jan 21, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Elizabeth M DuncanJohn V Lloyd

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