PMID: 8942989Nov 26, 1996Paper

Pepsin-inhibitory activity of the uterine serpins

Proceedings of the National Academy of Sciences of the United States of America
N Mathialagan, T R Hansen

Abstract

Among the major products secreted by the uteri of cattle, sheep, and pigs during pregnancy are glycoproteins with amino acid sequences that place them in the serpin (serine proteinase inhibitor) superfamily of proteins. The inferred amino acid sequences for bovine uterine serpin (boUS-1) and ovine uterine serpin (ovUS-1) exhibit about 72% sequence identity to each other but only about 50% and 56% identity, respectively, to two distinct porcine uterine serpins (poUS-1 and poUS-2). Despite these differences in primary structure, the uterine serpins possess well-conserved reactive center loop regions that contain several motifs present in the propeptide regions of pepsinogens. One such motif, VVVK, aligns with the first 4 amino acids of the aspartic proteinase inhibitor pepstatin. Although no inhibitory activity toward any serine proteinase has been found, at least one of the uterine serpins, ovUS-1, can bind specifically to immobilized pepsin A and can weakly inhibit the proteolytic activities of pepsin A and C (but not cathepsins D and E). OvUS-1 is the first specific inhibitor of aspartic proteinases to be identified in vertebrates and provides another example of a serpin with "crossover" activity. The pregnancy-associated glyc...Continue Reading

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Citations

Jul 2, 2005·The Journal of Allergy and Clinical Immunology·Sabina WünschmannAnna Pomés
Sep 27, 2000·Biochimica Et Biophysica Acta·M R PeltierP J Hansen
Jul 11, 2002·Animal Reproduction Science·Bozena Szafrañska, Grzegorz Panasiewicz
Jan 13, 2000·Proceedings of the Society for Experimental Biology and Medicine·M R PeltierP J Hansen
Jun 12, 2010·The Journal of Biological Chemistry·Stephen J HeadeySteven M Pascal
Oct 22, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·N M EllinwoodR A Bowen
Jul 7, 1999·American Journal of Reproductive Immunology : AJRI·W J LiuP J Hansen
Nov 11, 2005·The FEBS Journal·John T Christeller
Feb 25, 2005·American Journal of Reproductive Immunology : AJRI·Saban TekinPeter J Hansen
Sep 10, 2016·Molecular Reproduction and Development·Beenu Moza JalaliDariusz J Skarzynski
Feb 11, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Rhianna M WallaceJonathan A Green
Jun 17, 2009·Journal of Cellular Biochemistry·Maria B Padua, Peter J Hansen
Aug 4, 2010·American Journal of Reproductive Immunology : AJRI·Maria B Padua, Peter J Hansen
Oct 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria B PaduaPeter J Hansen
Sep 2, 2006·Experimental Biology and Medicine·Saban TekinPeter J Hansen
Dec 31, 2004·Molecular Reproduction and Development·Saban TekinPeter J Hansen

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