PMID: 6166128May 1, 1981Paper

Pepsin-treated human gamma globulin in bacterial infections. A randomized study in patients with septicaemia and pneumonia

Vox Sanguinis
L LindquistR Maasing

Abstract

59 patients with suspected or verified septicaemia and 87 patients with suspected or verified bacterial pneumonia were treated with either antibiotics alone or antibiotics combined with a pepsin-treated human gamma globulin (Gamma-Venin). The gamma globulin was given intravenously in repeated doses of 0.15 g/kg body weight. Extensive clinical and laboratory investigations were performed repeatedly in a strictly standardized fashion. Neither the septicaemia group nor the pneumonia group presented significant differences between treated patients and controls for any of the clinical and laboratory variables studied. Hospital stay, duration of fever and symptoms were also unaffected by the gamma globulin treatment. Subdivision of the material according to aetiology provided no additional information. In 9 patients adverse reactions were seen, e.g., shock in 2 individuals.

Citations

Aug 1, 1983·Klinische Wochenschrift·H H SedlacekF R Seiler
Aug 14, 2012·Current Infectious Disease Reports·Susanne Toussaint, Herwig Gerlach
Jun 19, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julie Pildal, Peter C Gøtzsche
Dec 13, 2007·Critical Care Medicine·K Georg KreymannStefan Kluge
Mar 20, 2012·Critical Care : the Official Journal of the Critical Care Forum·Manu Shankar-HariMervyn Singer
Nov 6, 2018·Minerva anestesiologica·Tamas Szakmany
Oct 1, 1995·Zentralblatt für Veterinärmedizin. Reihe A·A R AbadiaM A Bregante
Sep 18, 2013·The Cochrane Database of Systematic Reviews·Marissa M AlejandriaJacinto Blas Mantaring

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