PMID: 8466308Apr 1, 1993Paper

Peptic ulcer surgery in patients with liver cirrhosis

Annals of Surgery
T Lehnert, C Herfarth

Abstract

This study identified risk factors of surgical treatment for gastroduodenal ulcer disease in patients with liver cirrhosis. Liver cirrhosis is frequently associated with complicated peptic ulcer disease. Surgery in liver cirrhotics has a high mortality and morbidity especially when abdominal operations are performed. Sixty-nine patients undergoing surgery for gastroduodenal ulcer disease between 1972 and 1991 were studied, retrospectively. Ninety percent of patients required emergency surgery for bleeding ulcer (n = 45) or perforation (n = 17). Mortality was 29% for elective patients (n = 7), 35% for patients with perforation and 64% for patients with bleeding. Overall mortality of 69 patients was 54%. Only 15 of 69 patients (22%) had an uncomplicated postoperative course. Postoperative bleeding, septic complications, and renal failure were the most frequent postoperative complications. Bleeding and multiple organ failure were the leading causes of death in 70% of patients. A univariate analysis determined preoperative hemoglobin < 12 g/L (p < 0.05), systolic blood pressure < 100 mm Hg (p < 0.025), prothrombin time < 60% (p < 0.05) and the presence of portal hypertension (p < 0.01) as prognostic factors. No significant correlat...Continue Reading

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Citations

May 18, 2005·Journal of Clinical Anesthesia·Ramsey C CheungJohn B Pollard
Nov 15, 2002·Nutrition·Manuela MerliOliviero Riggio
Nov 1, 2000·Critical Care : the Official Journal of the Critical Care Forum·S P PovoskiL H Blumgart
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Apr 2, 2013·The Spine Journal : Official Journal of the North American Spine Society·Jen-Chung LiaoTsung-Ting Tsai
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