PMID: 9422334Jan 9, 1998Paper

Peptidases in human bronchoalveolar lining fluid, macrophages, and epithelial cells: dipeptidyl (amino)peptidase IV, aminopeptidase N, and dipeptidyl (carboxy)peptidase (angiotensin-converting enzyme)

The Journal of Laboratory and Clinical Medicine
L Juillerat-JeanneretP Leuenberger

Abstract

The modulation of proteolytic activity is an important factor in regulating the metabolism and function of peptide hormones. In this study, the activities of dipeptidyl (carboxy)peptidase (angiotensin-converting enzyme [ACE]), aminopeptidase N (APN), and dipeptidyl (amino)peptidase IV (DPP IV) were measured in the blood, the human bronchial epithelial and alveolar cells, bronchoalveolar macrophages, and the soluble phase of bronchoalveolar lavage (BAL) samples obtained from normal human volunteers and patients with pulmonary pathologic conditions. BAL fluid expressed ACE activity and very low levels of APN and DPP IV activities in the volunteer population, but higher levels could be measured in samples from patients. In patients, increased APN corresponded to a high granulocyte count, while DPP IV and ACE were associated with a high percentage of lymphocytes. Neither AIDS nor smoking induced an increased level of these enzymes. Immunohistochemical staining of bronchoalveolar smears with anti-human ACE monoclonal antibody showed that only macrophages expressed this enzyme. Enzyme histochemistry for DPP IV and APN showed that all leukocytes expressed these activities. APN, DPP IV, and ACE activities were also found in cell extrac...Continue Reading

References

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Citations

Mar 12, 2003·Bioorganic & Medicinal Chemistry·Yann BergerLucienne Juillerat-Jeanneret
May 21, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V H Van Der VeldenM A Versnel
Jun 22, 2005·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·A SteimerC-M Lehr
Jan 16, 2002·American Journal of Respiratory and Critical Care Medicine·Kai NowakMartha-Maria Gebhard
Dec 15, 2012·American Journal of Respiratory Cell and Molecular Biology·Mulugu V BrahmajothiRichard L Auten
Sep 13, 2006·Veterinary Pathology·B GruborM R Ackermann
Oct 31, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jutta SchadeStephan von Hörsten
Mar 18, 2004·International Journal of Cancer. Journal International Du Cancer·Umadevi V WesleyAlan N Houghton
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T S LiangP M Murphy

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