Peptide and non-peptide mimetics as potential therapeutics targeting oral bacteria and oral biofilms

Molecular Oral Microbiology
Maryta N SztukowskaDonald R Demuth

Abstract

The development of the oral biofilm requires a complex series of interactions between host tissues and the colonizing bacteria as well as numerous interspecies interactions between the organisms themselves. Disruption of normal host-microbe homoeostasis in the oral cavity can lead to a dysbiotic microbial community that contributes to caries or periodontal disease. A variety of approaches have been pursued to develop novel potential therapeutics that are active against the oral biofilm and/or target specific oral bacteria. The structure and function of naturally occurring antimicrobial peptides from oral tissues and secretions as well as external sources such as frog skin secretions have been exploited to develop numerous peptide mimetics and small molecule peptidomimetics that show improved antimicrobial activity, increased stability and other desirable characteristics relative to the parent peptides. In addition, a rational and minimalist approach has been developed to design small artificial peptides with amphipathic α-helical properties that exhibit potent antibacterial activity. Furthermore, with an increased understanding of the molecular mechanisms of beneficial and/or antagonistic interspecies interactions that contribu...Continue Reading

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Citations

Aug 5, 2020·Expert Opinion on Drug Discovery·Farshid ZandsalimiZeinab Zohrab Zadeh
Nov 17, 2020·Frontiers in Microbiology·Rojita MishraJunaid Khan
Mar 17, 2020·Biochimica Et Biophysica Acta. Biomembranes·Nermina MalanovicEnrico F Semeraro
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jamie TooleFionnuala T Lundy

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Methods Mentioned

BETA
amidation
peptide array

Clinical Trials Mentioned

NCT03196219

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