Peptide and peptide analog transport systems at the blood-CSF barrier

Advanced Drug Delivery Reviews
David E SmithRichard F Keep

Abstract

In addition to being the main source of cerebrospinal fluid (CSF) secretion, the choroid plexuses are involved in the supply and distribution of peptides to brain, the removal of toxic metabolites, the excretion of xenobiotics, and the delivery of drugs as an alternative route to the blood-brain barrier (BBB). The discovery of proton-coupled oligopeptide transporters in choroid plexus has generated considerable interest regarding their physiologic role at the blood-cerebrospinal fluid interface and their potential for peptide/antagonist pharmacotherapy in the central nervous system. Many of the same factors that affect the disposition of naturally occurring peptides in brain will also affect the disposition of exogenously delivered peptide or peptidomimetic drugs. Therefore, this review addresses three main areas: (1) choroid plexus structure, physiology, and barrier function in relation to peptide transport; (2) polypeptide transport and secretion mechanisms into cerebrospinal fluid; and (3) molecular physiology, expression, and functional activity of proton-coupled oligopeptide transporters in choroid plexus.

Citations

Jul 20, 2005·Pharmaceutical Research·Conrad E JohansonAndrew Baird
Oct 19, 2006·Pharmaceutical Research·Reynold Spector, Conrad Johanson
Mar 21, 2007·Pharmaceutical Research·Reynold Spector, Conrad E Johanson
May 18, 2010·Pharmaceutical Research·Reynold Spector, Conrad E Johanson
Oct 13, 2006·Brain Research·Jianming XiangRichard F Keep
Apr 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Pei-Yu WangIan S McLennan
Apr 12, 2007·Behavioural Pharmacology·Radmila MileusnicSteven P R Rose
Apr 19, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F Mashayekhi, Z Salehi
Jan 31, 2009·The Journal of Pharmacology and Experimental Therapeutics·Amber DahlinJoanne Wang
Feb 1, 2005·Cerebrospinal Fluid Research·Conrad JohansonEdward Stopa
May 16, 2008·Cerebrospinal Fluid Research·Conrad E JohansonGerald D Silverberg
Sep 26, 2013·Fluids and Barriers of the CNS·Reynold Spector, Conrad E Johanson
Jul 12, 2011·Fluids and Barriers of the CNS·Crissey L PascaleGerald D Silverberg
Nov 8, 2011·Fluids and Barriers of the CNS·Richard F Keep, David E Smith
Jan 15, 2014·Molecular Brain·Reynold Spector, Conrad E Johanson
Nov 22, 2014·Fluids and Barriers of the CNS·Xiaomei ChenMargareta Hammarlund-Udenaes
Dec 1, 2011·Translational Stroke Research·Richard L Benton, Theo Hagg
Jun 13, 2009·Expert Opinion on Drug Metabolism & Toxicology·Matthias Brandsch
Mar 10, 2015·Experimental Neurology·Reynold SpectorConrad E Johanson
Mar 20, 2013·Molecular Aspects of Medicine·David E SmithMatthias A Hediger
Jun 12, 2010·Brain Research·Jianming XiangRichard F Keep
Nov 17, 2009·Advanced Drug Delivery Reviews·Ho Lun WongReina Bendayan
May 5, 2009·Neurobiology of Learning and Memory·Rink-Jan LohmanThomas M Cocks
Apr 28, 2009·Progress in Neurobiology·Ivona BrasnjevicUNKNOWN European NanoBioPharmaceutics Research Initiative
Apr 23, 2009·Journal of Neurochemistry·Huidi JiangDavid E Smith
Feb 10, 2009·The European Journal of Neuroscience·Shane A LiddelowNorman R Saunders
Apr 18, 2008·The Journal of Pharmacy and Pharmacology·Matthias BrandschEva Bosse-Doenecke
Mar 22, 2012·Medicinal Research Reviews·Patrick Vlieghe, Michel Khrestchatisky
Mar 21, 2016·Journal of Neuropathology and Experimental Neurology·G R Wayne MooreMargaret M Esiri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood-Brain Barrier Transport in Neurodegeneration

The blood brain barrier is important for regulating the movement of biomolecules in and out of the brain. For example, membrane transporters in the blood brain barrier can be essential for regulating drug movement and dysregulation of these processes may play a role in neurodegeneration. This feed follows the latest research on this topic.

Alzheimer's Disease: Endosomes

Dysfunctional endosomal trafficking may be associated with Alzheimer’s disease (AD) pathology. Targeting the endosome may advance treatment options for AD. Here is the latest research on endosomes and AD.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.