Peptide antibiotics in action: investigation of polypeptide chains in insoluble environments by rotational-echo double resonance

Biochimica Et Biophysica Acta
Orsolya TokeJacob Schaefer

Abstract

Rotational-echo double resonance (REDOR) is a solid-state NMR technique that has the capability of providing intra- and intermolecular distance and orientational restraints in non-crystallizable, poorly soluble heterogeneous molecular systems such as cell membranes and cell walls. In this review, we will present two applications of REDOR: the investigation of a magainin-related antimicrobial peptide in lipid bilayers and the study of a vancomycin-like glycopeptide in the cell walls of Staphylococcus aureus.

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Citations

Jun 8, 2010·Journal of Medicinal Chemistry·Jed F Fisher, Shahriar Mobashery
Nov 11, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Dong-Kuk LeeAyyalusamy Ramamoorthy
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