Peptide aptamers: tools for biology and drug discovery

Briefings in Functional Genomics & Proteomics
Margaret CrawfordPaul Ko Ferrigno

Abstract

Peptide aptamer technology is relatively youthful. It has the advantage over existing techniques that the reagents identified are designed for expression in eukaryotic cells. This allows the construction of molecular tools that allow the logic of genetics, from knockouts to extragenic suppressors, to be applied to studies of proteins in tissue culture cells. Until recently, the available tools have limited our understanding of cell biology. The same limitation restricts out ability to validate the numerous candidate drug targets emerging from genome-wide approaches to cellular biology. Peptide aptamers represent a stride forwards in the evolution of a modular, molecular tool kit for cell biology and for drug target validation. The authors predict that they will also play a role in the transition from genomic to proteomic microarray technology.

Citations

Dec 10, 2009·The American Journal of Bioethics : AJOB·Fritz Allhoff
Feb 26, 2011·Vascular Cell·Deboshri BanerjeeShiladitya Sengupta
Jan 31, 2014·Molecular Biology of the Cell·Karolina LeśniewskaHiroyuki Ohkura
Feb 23, 2011·International Journal of Molecular Sciences·Francisco Javier Fernández AceroJesús M Cantoral
Nov 19, 2010·British Journal of Haematology·Simon D WagnerPaul Ko Ferrigno
Jan 4, 2012·Angewandte Chemie·Marco MasciniSara Tombelli
Dec 27, 2005·Current Opinion in Genetics & Development·Gilbert G Privé, Ari Melnick
Nov 1, 2005·Biochemical and Biophysical Research Communications·Jing MiBryan M Clary
Sep 19, 2014·The Plant Journal : for Cell and Molecular Biology·Pichang GongChaoying He
Feb 5, 2008·Antiviral Research·Alla TrahtenhertsItai Benhar
Aug 27, 2016·Cellular and Molecular Life Sciences : CMLS·Jing QuJianliang Zhang
May 4, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ari M MelnickJonathan D Licht
Jul 22, 2016·Biosensors·Marcus MengerFrieder W Scheller
Mar 7, 2006·Nature Reviews. Drug Discovery·Eugene W M NgAnthony P Adamis
Feb 5, 2019·Critical Reviews in Food Science and Nutrition·Caleb AcquahMichael Kobina Danquah
Oct 9, 2007·Journal of Molecular Recognition : JMR·Matthias PaschkeWolfgang Höhne
Dec 7, 2005·Oncogene·A ChattopadhyayP Ko Ferrigno
May 24, 2006·The Journal of Biological Chemistry·Evangelia TomaiFelix Hoppe-Seyler
Jul 7, 2007·The International Journal of Neuroscience·Enikö Raceková, Judita Orendácová
Dec 21, 2007·Journal of Bone and Mineral Metabolism·Kimiko MiyaharaKeiki Ogino
Nov 30, 2018·Genes·Juan David Ospina-VillaLaurence A Marchat
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yoon Pin Lim
Dec 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Cheng-Yi HuangChun-Lin Chen
Jul 25, 2020·Current Topics in Medicinal Chemistry·Huan-Rong LanShi-Bing Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved