PMID: 8608184Nov 1, 1995Paper

Peptide attachment to extremities of liposomal surface grafted PEG chains: preparation of the long-circulating form of laminin pentapeptide, YIGSR

Bioconjugate Chemistry
S ZalipskyM C Woodle

Abstract

Poly(ethylene glycol) (PEG)-grafted liposomes offer new opportunities as long-circulating platforms presenting biologically relevant ligands. In pursuit of this goal, liposomal conjugates of YIGSR were prepared by mild periodate oxidation of TYIGSR-NH2 and incubation of the product with hydrazide-PEG-(distearoylphosphatidyl)ethanolamine-containing liposomes. The peptide-carrying liposomes, with up to 500 YIGSR residues per vesicle, despite exhibiting faster blood clearance rates than the parent liposomes in rats, remained in circulation for extended periods of time. Mean residence times for the parent liposomal formulation and conjugated preparations containing 200 and 500 YIGSR residues per vesicle were 28, 25, and 23 h, respectively. The results have important implications for systemic delivery of peptides and for their use as targeting moieties for PEG-grafted liposomes.

References

May 1, 1992·Bioconjugate Chemistry·H F GaertnerR E Offord
Aug 14, 1992·Biochimica Et Biophysica Acta·M C Woodle, D D Lasic
Mar 3, 1995·Science·D D Lasic, D Papahadjopoulos
Jul 1, 1993·Bioconjugate Chemistry·J A BraatzA H Heifetz
Jul 20, 1995·Analytical Biochemistry·E K OtoP S Uster

❮ Previous
Next ❯

Citations

Jan 27, 1999·Biochimica Et Biophysica Acta·J R StarkeyE A Dratz
Jan 9, 2001·Trends in Biotechnology·J Gariépy, K Kawamura
Sep 1, 2000·Advanced Drug Delivery Reviews·S P Vyas, V Sihorkar
Jun 6, 2000·Advanced Drug Delivery Reviews·M Willis, E Forssen
Jun 6, 2000·Advanced Drug Delivery Reviews·M C Woodle
Jun 6, 2000·Advanced Drug Delivery Reviews·W T Phillips
Jul 1, 2009·Future Medicinal Chemistry·Martin J GarlandRyan F Donnelly
Dec 1, 2001·Expert Opinion on Biological Therapy·N MaurerP R Cullis
Jul 8, 2010·Journal of Drug Targeting·Vaibhav DubeyN K Jain
Jan 27, 2016·Journal of Bioscience and Bioengineering·Jinhua DongHiroshi Ueda
Apr 13, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M Wang, M Thanou
Jan 18, 2008·Biophysical Journal·Hyunsook JungPaul S Cremer
Jul 23, 2004·Expert Opinion on Therapeutic Targets·Charles O NobleDaryl C Drummond
Apr 1, 2015·Chemistry and Physics of Lipids·Christophe SaloméLine Bourel-Bonnet
Apr 13, 2013·Bioconjugate Chemistry·Ouafâa El-Mahdi, Oleg Melnyk
Mar 26, 2014·Biomacromolecules·Alice W Du, Martina H Stenzel
Mar 30, 2004·Preparative Biochemistry & Biotechnology·Núria AlmiñanaFrancesca Reig
Mar 5, 2004·Journal of Biomedical Materials Research. Part a·L A Lopez-BarconsA Fabra
Dec 16, 2003·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Iren ConstantinescuMaria Gyongyossy-Issa
Jul 25, 1997·Biochimica Et Biophysica Acta·J A HardingS Zalipsky
Jul 18, 2006·Journal of Colloid and Interface Science·Muthuselvi Lakshmanan, Aruna Dhathathreyan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.