Peptide-based anticancer vaccines: recent advances and future perspectives

Current Medicinal Chemistry
S MocellinD Nitti

Abstract

Anticancer active immunotherapy embodies the ideal antitumor therapy, as it theoretically combines target specificity with long-term disease control. Peptide-based cancer vaccines represent the most specific approach to polarize the immune system against malignant cells, since they are preparations made of single epitopes, the minimal immunogenic region of an antigen. Despite the strong rational, the promising preclinical results and the frequent induction of antigen-specific immune responses, peptide-based cancer vaccines have yielded relatively poor results in the clinical setting, a phenomenon likely due to the immunosuppressive properties of the tumor microenvironment that allow malignant cells to evade both naturally occurring and therapeutically induced immune surveillance. Nevertheless, advances in the engineering of peptides and in our understanding of the molecular mechanisms underlying an effective immune response against tumors have renewed the enthusiasm for peptide-based vaccination regimens in the setting of cancer, and a variety of clinical trials are being conducted based on the use of peptides. This review will describe the most recent insights in the rational design of peptide-based cancer vaccines, as well as...Continue Reading

Citations

Jun 27, 2013·Journal of Chemical Information and Modeling·Ivan Tubert-BrohmanThijs Beuming
Jul 10, 2010·Journal of Biomedicine & Biotechnology·Roberto Bei, Antonio Scardino
Sep 17, 2011·Clinical & Developmental Immunology·Shigeo KoidoHisao Tajiri
Jan 1, 2014·World Journal of Gastroenterology : WJG·Shigeo KoidoHisao Tajiri
Aug 13, 2010·Clinical Medicine Insights. Oncology·Joseph F Murphy
Apr 22, 2011·Current Opinion in Chemical Biology·Monica C BrancoJoel P Schneider
Aug 17, 2010·Peptides·Lidia FeliuTeresa Puig
Jul 14, 2010·Vaccine·Fu-Ling ZhouBai-Yan Wang
Nov 16, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·David S FinleyJean B Dekernion
Sep 17, 2011·Medicinal Research Reviews·Frederick HarrisDavid A Phoenix
Jun 3, 2015·Cancer Immunology, Immunotherapy : CII·Maria Grazia CusiPierpaolo Correale
May 30, 2013·International Immunopharmacology·Zhong-Li LiaoShi-Ming Yang
Dec 9, 2014·Human Vaccines & Immunotherapeutics·Amedeo AmedeiDomenico Prisco
Nov 29, 2013·Oncoimmunology·Erika VacchelliLorenzo Galluzzi
Mar 20, 2013·BioMed Research International·Elena NiccolaiAmedeo Amedei
Feb 7, 2018·The Cochrane Database of Systematic Reviews·Sandro PasqualiSimone Mocellin
Jun 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacqueline Tung, Andrea J Sant
Jan 22, 2019·Journal of Immunology Research·Ren-You PanShuen-Iu Hung
Jul 3, 2020·Nanomaterials·Vanessa Acebes-FernándezManuel Fuentes
Jun 15, 2021·Frontiers in Cellular and Infection Microbiology·Pablo Juanes-VelascoManuel Fuentes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.