Peptide-based nanoprobes for molecular imaging and disease diagnostics

Chemical Society Reviews
Pengcheng ZhangHonggang Cui

Abstract

Pathological changes in a diseased site are often accompanied by abnormal activities of various biomolecules in and around the involved cells. Identifying the location and expression levels of these biomolecules could enable early-stage diagnosis of the related disease, the design of an appropriate treatment strategy, and the accurate assessment of the treatment outcomes. Over the past two decades, a great diversity of peptide-based nanoprobes (PBNs) have been developed, aiming to improve the in vitro and in vivo performances of water-soluble molecular probes through engineering of their primary chemical structures as well as the physicochemical properties of their resultant assemblies. In this review, we introduce strategies and approaches adopted for the identification of functional peptides in the context of molecular imaging and disease diagnostics, and then focus our discussion on the design and construction of PBNs capable of navigating through physiological barriers for targeted delivery and improved specificity and sensitivity in recognizing target biomolecules. We highlight the biological and structural roles that low-molecular-weight peptides play in PBN design and provide our perspectives on the future development of...Continue Reading

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Methods Mentioned

BETA
imaging techniques
fluorescence imaging
fluorescence resonance
glycosylation
Peptide library construction
phage display
enzymatic cleavage
imaging technique
surface-enhanced Raman scattering
BRET

Clinical Trials Mentioned

NCT02391194
NCT02608203
NCT02691078
NCT03136328
NCT01879657
NCT03145857
NCT02464332
NCT02496065
NCT02462629
NCT02234297

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