Feb 1, 1976

Peptide-binding macromolecules in the blood of seriously ill or mentally retarded patients

The Journal of Laboratory and Clinical Medicine
T L GoodfriendJ M Stewart

Abstract

This report describes macromolecules that bind (des-aspartic acid1)-angiotensin II, the des aspartic acid1 derivative of angiotensin I, and several biologically active and inactive analogues of these polypeptides. The macromolecules were found in the plasma of approximately 2 per cent of ambulatory adults and hospitalized children and 32 per cent of the patients at two institutions for the mentally retarded. The binding properties of these macromolecules were studied by incubating with peptides labeled with 125iodine, and separating bound from free labeled peptide using small gel filtration columns. The peptide-binding macromolecules from several patients were compared. They showed very similar specificity for a group of arginyl peptides of the des-aspartyl1-angiotensin sequence. The plasma binders differed from one another in their optimum pH and their mobility in electrophoretic fields. Those with more acid pH optima displayed more rapid electrophoretic mobility. The binders fell into two classes based on apparent molecular weight, approximately 140,000 and 250,000. Those with the higher apparent molecular weight contained a large proportion of binder that could be precipitated with antiserum to human IgA. Kinetic measurement...Continue Reading

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Mentioned in this Paper

Calcium [EPC]
Calcium
Immune Sera
Mentally Disabled Persons
MED25 gene
Plasma Protein Binding Capacity
AGT
Streptomycin
Immunoglobulin A, Human
Trypsin

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