PMID: 4897024May 1, 1969Paper

Peptide chain termination. 3. Stimulation of in vitro termination

Proceedings of the National Academy of Sciences of the United States of America
G MilmanT Caskey

Abstract

Throughout extensive purification, the release factors R(1) and R(2) each behave as a single molecular species with alternate codon recognition (R(1), UAA or UAG; R(2), UAA or UGA). The release of f[(3)H]methionine from f[(3)H]-Met-tRNA.AUG.ribosome complex requires R factor and terminator codon and does not appear to require tRNA or transfer factors T and G. Purification of the components of the release assay has enabled identification of a protein factor S in the 55-80 per cent ammonium sulfate fraction of E. coli B supernatant fraction which stimulates the rate but not the extent of release dependent upon R factor and appropriate termination codon. The S factor has properties similar to T, but further purification is required to determine the nature and function of S in peptide chain termination.

References

Jun 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·J Lucas-Lenard, F Lipmann
Oct 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·J E AllendeH Weissbach
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·E ScolnickM Nirenberg
Sep 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·M R Capecchi
Jun 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·J M Ravel
Feb 4, 1967·Nature·S BrennerF H Crick
Oct 15, 1961·Proceedings of the National Academy of Sciences of the United States of America·J H MATTHAEI, M W NIRENBERG

❮ Previous
Next ❯

Citations

May 1, 1994·Current Genetics·I Stansfield, M F Tuite
Dec 1, 1970·Die Naturwissenschaften·L Träger
Dec 20, 1974·Molecular and Cellular Biochemistry·W P Tate, C T Caskey
Oct 15, 1970·Biochimica Et Biophysica Acta·J R MenningerW S Stirewalt
Dec 20, 2002·Biology of the Cell·Bertrand CossonGalina Zhouravleva
Feb 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·J GoldsteinT Caskey
Mar 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·R K TompkinsC T Caskey
May 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·H Ishitsuka, A Kaji
Aug 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·R K Tompkins
Oct 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·J L Goldstein, C T Caskey
Dec 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·C T CaskeyM Rosman
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M C GanozaS L Phillips
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·W P TateC T Caskey
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·N BrotH Weissbach
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·G GrentzmannR H Buckingham
Jul 9, 2008·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Kiyohito KihiraYoshiki Higuchi
Dec 15, 1995·European Journal of Biochemistry·K K MortensenH U Sperling-Petersen
Nov 8, 2006·Molekuliarnaia biologiia·V V Hauryliuk
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·D V FreistrofferM Ehrenberg
Dec 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·E M Scolnick, C T Caskey
Aug 18, 1976·Biochimica Et Biophysica Acta·Y UeharaH Umezawa
Jun 1, 1977·Archives of Biochemistry and Biophysics·J C Ratliff, C T Caskey
Apr 5, 1978·Journal of Molecular Biology·I L Armstrong, W P Tate
Feb 28, 1971·Journal of Molecular Biology·J Ninio
Apr 15, 1975·Journal of Molecular Biology·W P Tate, C T Caskey
Oct 12, 1979·Biochemical and Biophysical Research Communications·J M CampbellC T Caskey
Sep 30, 1970·Biochemical and Biophysical Research Communications·M C Ganoza, J K Tomkins
Jun 19, 2015·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Tit-Yee Wong, Steve D Schwartzbach
Jun 15, 2016·Molecular Biology and Evolution·Yulong WeiXuhua Xia
Jan 10, 1970·Nature·E ScolnickT Caskey
Jul 4, 1970·Nature·A L Beaudet, C T Caskey
Dec 15, 1994·Nature·M F Tuite, I Stansfield
Jun 1, 1990·Molecular Microbiology·W J CraigenC T Caskey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
J L GoldsteinT Caskey
Proceedings of the National Academy of Sciences of the United States of America
O MikuniY Nakamura
Proceedings of the National Academy of Sciences of the United States of America
G GrentzmannR H Buckingham
Proceedings of the National Academy of Sciences of the United States of America
E ScolnickM Nirenberg
© 2021 Meta ULC. All rights reserved