Oct 26, 1989

Peptide-dependent recognition of H-2Kb by alloreactive cytotoxic T lymphocytes

Nature
W R HeathL A Sherman

Abstract

Antigen-specific T lymphocytes appear to recognize foreign antigens in the form of peptide fragments presented within the antigen-binding groove of class I or class II molecules encoded by the major histocompatibility complex (MHC). Alloreactive T cells also show specificity for MHC molecules, and various reports suggest that residues of the MHC molecules constitute at least part of the ligand to which alloreactive T-cell receptors bind. The X-ray crystal structure of the human MHC class I molecule, HLA-A2, has provided evidence to strengthen the argument that MHC-bound self-peptide might also contribute to such recognition. We now provide direct evidence for this, showing that at least some alloreactive cytotoxic T lymphocyte clones recognize peptide fragments derived from cytoplasmic proteins. We reasoned that if self-peptides were involved in allorecognition, then the sequence of some of these peptides could vary between species, resulting in species-restricted distribution of the relevant ligand(s). Several alloreactive cytotoxic T lymphocyte clones specific for H-2Kb, expressed by the murine cell line EL4, did not lyse a human-cell transfectant expressing the H-2Kb molecule (Jurkat-Kb cells). However, these clones were abl...Continue Reading

Mentioned in this Paper

T-Lymphocyte
TC2 Cells
Amino Acids, I.V. solution additive
Murine
Plain X-ray
Antigenic Specificity
Cytotoxic T-Lymphocytes
Endopeptidases
Proteolytic Enzyme
Bromides Measurement

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