PMID: 7528355Aug 1, 1994Paper

Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease: a review

Neurochemical Research
V K Tuohy

Abstract

This article reviews recent advances in understanding the role of myelin proteolipid protein (PLP) in autoimmune demyelination. It is drawn largely from work published within the last ten years and discusses the immunology of PLP in the historical context of what has been learned from extensive studies on the immune response to myelin basic protein (MBP). Despite the fact that PLP is the major protein constituent of mammalian myelin, its role in autoimmune demyelination has not been widely recognized. The lack of understanding about the immunology of PLP is a direct result of the biochemical characteristics of the protein. PLP is a highly hydrophobic membrane protein with limited aqueous solubility. The hydrophobicity of PLP has thwarted immunologic studies of the intact protein. Recent work has circumvented the technical obstacles of studying the intact protein by using soluble synthetic PLP peptides. This approach has rapidly resulted in a more definitive understanding of the immune response to PLP. Presently, the data indicate that: i) PLP is a major central nervous system (CNS) specific encephalitogen; ii) CD4+ T cell reactivity to discrete PLP peptide determinants can mediate the development of acute, chronic relapsing, an...Continue Reading

References

May 1, 1992·Journal of Neuroimmunology·R C van der VeenJ A Kapp
Jan 1, 1990·International Archives of Allergy and Applied Immunology·M EndohT Tabira
Jan 1, 1991·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·V K KuchrooM B Lees
Feb 1, 1991·Journal of Neuroscience Research·W F HickeyH Kimura
Sep 1, 1990·Journal of Neuropathology and Experimental Neurology·R A SobelM B Lees
May 1, 1985·Journal of the Neurological Sciences·T YoshimuraT Tabira
Aug 1, 1985·Annals of Neurology·M B Lees, F Cambi
Sep 1, 1985·Journal of the Neurological Sciences·G R MooreC S Raine
Jan 1, 1987·International Archives of Allergy and Applied Immunology·T NamikawaT Tabira
Jun 1, 1987·Journal of the Neurological Sciences·J L TrotterJ D Scarpellini
Apr 1, 1988·Journal of Neuroimmunology·N T Potter, M B Lees
May 1, 1988·The Journal of Experimental Medicine·S S ZamvilH Acha-Orbea
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K SakaiL Steinman
Jan 1, 1988·Annals of the New York Academy of Sciences·V K TuohyM B Lees
Mar 1, 1989·Journal of Neuroimmunology·C N BaxevanisM Papamichail
Feb 1, 1989·European Journal of Immunology·J ChlubaJ T Epplen

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Citations

Apr 20, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jane E LibbeyRobert S Fujinami
Jan 22, 2005·Immunology and Cell Biology·Yanina DitamoGerman A Roth
Dec 1, 1995·The Journal of Clinical Investigation·C P GenainS L Hauser
Apr 1, 1997·The Journal of Clinical Investigation·V K TuohyR P Kinkel
Sep 25, 1999·Journal of Neuroimmunology·P Diaz-VillosladaS L Hauser
Oct 16, 2015·Journal of Neurochemistry·Xiangyou HuRiqiang Yan
Oct 1, 1995·Clinical Immunology and Immunopathology·R H Swanborg
Jun 1, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Kaja KasarelloAgnieszka K Szczepankowska
Apr 26, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M PietropaoloM P Happ
Jun 1, 2016·Frontiers in Immunology·Soumya S Yandamuri, Thomas E Lane
Nov 18, 2000·European Journal of Biochemistry·A VincentB Lang
Oct 8, 1998·Multiple Sclerosis : Clinical and Laboratory Research·P StinissenJ Raus
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S B SuR R Caspi
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shao Bo SuRachel R Caspi
Dec 8, 2006·Neurochemical Research·Asgar ZaheerRamon Lim
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wanqiu HouBing Sun
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C M PelfreyP V Lehmann
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shao Bo SuRachel R Caspi
Aug 4, 2020·Journal of Translational Autoimmunity·Salvatore Cavallo

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