Peptide-DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

Organic & Biomolecular Chemistry
Elena PazosJosé L Mascareñas

Abstract

We describe a ds-oligonucleotide-peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as disrupters of AP-1-mediated gene expression pathways.

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Citations

Aug 26, 2015·Chembiochem : a European Journal of Chemical Biology·Luke F VistainThomas J Meade
Aug 16, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Matt GoodingCaitriona M O'Driscoll
Jun 7, 2017·Chemical Communications : Chem Comm·Yara Ruiz GarcíaAnnemieke Madder
Feb 12, 2017·Angewandte Chemie·Eric ValeurAlleyn T Plowright
Oct 27, 2017·Organic & Biomolecular Chemistry·James W WaltonPaul J Dyson
Jun 1, 2018·Chemical Society Reviews·Yushi BaiDavid G Lynn
Apr 30, 2021·Chemistry : a European Journal·Niall M McLoughlinTom N Grossmann
Oct 24, 2017·Journal of the American Chemical Society·Soraya Learte-AymamíJosé L Mascareñas

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