PMID: 7524117May 26, 1994Paper

Peptide-evoked release of amylase from isolated acini of the rat parotid gland

Regulatory Peptides
R GollJ J Holst

Abstract

Investigations of the effects of the neuropeptides, substance P (SP), neurokinin A (NKA), neuropeptide K (NPK), gastrin releasing peptide (GRP), calcitonin gene related peptide (CGRP) and vasoactive intestinal peptide (VIP), and of acetylcholine on amylase secretion have been carried out on isolated acini of the rat parotid gland. Furthermore, the occurrence and location of the peptides in the gland was studied. Finally, binding of 125I-BH-SP to isolated acini were studied in order to characterize their tachykinin receptor(s) and their binding kinetics. Only SP, NKA, NPK and VIP stimulated amylase release. VIP, however, with a rather low potency (EC50 at 155 nmol/l). Simultaneous stimulation with two compounds elicited additive responses, except for VIP and acetylcholine which elicited an effect significantly above additive response. Only SP, NKA, VIP and CGRP could be identified in extracts of the gland. The immunoreactivity of these peptides could be located to varicose nerve fibers in the gland. Binding of labeled SP to the isolated acini exhibited the characteristics of a genuine agonist/receptor interaction, and the rank order of displacement potencies indicated the presence of NK1-receptors. Thus, the results of the prese...Continue Reading

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Citations

Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
Jan 29, 1997·Regulatory Peptides·U HöckerfeltS Forsgren
Sep 7, 2007·Annals of the New York Academy of Sciences·Maria JönssonSture Forsgren
Aug 1, 1995·Archives of Physiology and Biochemistry·J Damas
Oct 15, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Joseph F PierreKenneth A Kudsk
Feb 2, 2008·Bioelectromagnetics·Amanda JohanssonMonica Sandström

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