PMID: 16637287Apr 28, 2006Paper

Peptide fragment 66-77 of monocyte chemoattractant protein 1 and its retro-enantio analogue inhibits the migration of cells in vitro and in vivo

Bioorganicheskaia khimiia
M V SidorovaV N Bushuev

Abstract

The retro-enantio analogue of peptide 66-77 of the chemokine MCP-1 and two hexapeptide fragments 66-71 and 72-77 of the C-terminal sequence of this protein were synthesized using the Fmoc strategy of solid phase peptide synthesis. The effect of the synthetic peptides upon the MCP-1-stimulated migration of THP-1 mononuclear cells was studied in vitro. The activity of the retro-enantio analogue was found to be comparable with that of the initial peptide 66-77: both peptides inhibit the migration of monocytes and granulocytes into inflammation zones of experimental animals.

References

Jul 1, 1969·Angewandte Chemie·M M ShemyakinV T Ivanov
Apr 29, 1998·Nature·M Baggiolini
Apr 13, 2000·Journal of Internal Medicine·P Libby
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Timothy S Olson, Klaus Ley

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