Peptide-Functionalized Nanomaterials for the Efficient Isolation of HER2-Positive Circulating Tumor Cells

ACS Applied Materials & Interfaces
Jiaxi PengYanlian Yang

Abstract

The detection of circulating tumor cells (CTCs) with a specific antigen expression is necessary in therapeutic response monitoring and targeted therapy guidance. The existence of human epidermal growth factor receptor 2 (HER2) and the concentration of HER2-positive CTCs are strong indicators for patient diagnosis, prognosis, and therapeutic monitoring. Herein we report the direct isolation of HER2-positive CTCs by peptide-functionalized nanomaterials. We designed and screened out a peptide as an HER2 antibody alternative demonstrating high HER2 affinity and selectivity. This HER2 recognition peptide bound efficiently with HER2 at the ligand-binding domain. Efficient HER2-positive CTC capture and detection were demonstrated using magnetic nanoparticles functionalized with the HER2 recognition peptide.

References

Jun 28, 2001·Oncogene·J Mendelsohn, J Baselga
Oct 7, 2003·Oncogene·Sylvie MénardElda Tagliabue
Apr 20, 2004·Cancer Cell·Matthew C FranklinMark X Sliwkowski
Jun 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Songdong MengJonathan Uhr
Aug 20, 2004·The New England Journal of Medicine·Massimo CristofanilliDaniel F Hayes
Mar 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Massimo CristofanilliLeon W M M Terstappen
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine RiethdorfKlaus Pantel
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·AmirAli H TalasazRonald W Davis
Nov 17, 2009·Nature Nanotechnology·Ekaterina I GalanzhaVladimir P Zharov
Apr 22, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine RiethdorfKlaus Pantel
Oct 24, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nadire DuruJian Jian Li
Jan 22, 2013·Journal of the American Chemical Society·Xiaobo MaoChen Wang
Apr 9, 2015·ACS Applied Materials & Interfaces·Ning-Ning LuWei-Hua Huang
Jul 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Linling BaiChen Wang

❮ Previous
Next ❯

Citations

May 28, 2019·Journal of Nanobiotechnology·Monika RuzyckaIreneusz P Grudzinski
Jan 23, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Balram SinghJayant Khandare
Mar 9, 2019·ACS Applied Materials & Interfaces·Zhiru WangYuanqing Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.