Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner

Immunity
E SebzdaP S Ohashi

Abstract

T cell receptor (TCR) transgenic thymocytes specific for the LCMV gp peptide are normally positively selected to the CD8 lineage. Transgenic thymocyte development was substantially reduced in the absence of these CD8 coreceptors. However, efficient positive selection was restored when TCR transgenic CD8-/- fetal thymic lobes were cultured with a peptide variant of the wild-type ligand. These mature thymocytes were functional, as shown by their ability to respond against strong peptide agonists. Additional experiments demonstrated that transgenic positive selection was peptide-specific. These results prove that CD8 does not possess essential signaling properties that are necessary for T cell development. In addition, the unilateral commitment of transgenic thymocytes to mature CD4-TCR(hi) T cells expressing intracellular perforin suggests that there must be some instructive component to CD4 down-regulation and lineage commitment during thymocyte selection.

References

Nov 1, 1992·The Journal of Experimental Medicine·V A WallaceT W Mak
May 14, 1992·Nature·T J MolinaA Veillette
Jan 1, 1988·Immunological Reviews·J SprentY Ron
Apr 1, 1995·Current Opinion in Immunology·B J Fowlkes, E Schweighoffer
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·D M PageH M Grey
Apr 1, 1994·Current Opinion in Immunology·C B Davis, D R Littman
Sep 1, 1994·European Journal of Immunology·A RahemtullaT W Mak
Jun 30, 1994·Nature·S C JamesonM J Bevan
Sep 1, 1994·The Journal of Experimental Medicine·W P Fung-LeungC Y Lau
Aug 13, 1993·Science·J P van Meerwijk, R N Germain
Jan 14, 1994·Cell·K A HogquistF R Carbone
Jan 28, 1994·Cell·A Weiss, D R Littman
Aug 19, 1993·Nature·N Killeen, D R Littman
Mar 1, 1996·European Journal of Immunology·O WilliamsD Kioussis
Jun 13, 1996·Nature·S M AlamN R Gascoigne

❮ Previous
Next ❯

Citations

Feb 1, 2002·Human Immunology·Yoshihiro KobayashiYoshitaka Fujii
Jul 11, 1998·Biochimica Et Biophysica Acta·M A FarrarK Sauer
Jun 25, 1998·Current Opinion in Immunology·N KilleenK Zingler
May 29, 1998·Current Opinion in Immunology·S C Jameson, M J Bevan
Feb 11, 2004·Nature Immunology·Xiaolong Liu, Rémy Bosselut
Jan 20, 2009·Nature Reviews. Immunology·Ed Palmer, Dieter Naeher
May 30, 2002·Nature Reviews. Immunology·Ronald N Germain
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Derek B Sant'Angelo, Charles A Janeway
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·V P DaveD J Kappes
Dec 16, 1998·Immunological Reviews·S ChanD Mathis
Dec 16, 1998·Immunological Reviews·D Amsen, A M Kruisbeek
May 10, 2008·European Journal of Immunology·David S RiddleEdward J Collins
Dec 18, 2008·European Journal of Immunology·Satoshi KomaniwaKeiko Udaka
Jul 4, 2001·The Journal of Clinical Investigation·O de la Calle-MartinT Espanol
Jul 23, 2003·Immunity·Gabriela Hernández-HoyosJose Alberola-Ila
Jun 14, 2005·Cellular Immunology·Stanislav Vukmanović, Fabio R Santori
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·N WatanabeT Saito
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S J SohnR M Perlmutter
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kaisa HolmbergNicholas R J Gascoigne
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shaomin TianJeffrey A Frelinger
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dieter NaeherEd Palmer
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Justine D MinternEckart Schott
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaolong LiuRémy Bosselut
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T Sasada, E L Reinherz
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Troy A BaldwinStephen C Jameson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.