Peptide inhibitors of virus-cell fusion: enfuvirtide as a case study in clinical discovery and development

The Lancet Infectious Diseases
David A Cooper, Joep M A Lange

Abstract

The peptidic antiretroviral enfuvirtide (Fuzeon) is the first clinically approved antiviral fusion inhibitor and the first antiretroviral that must routinely be administered parenterally. Its extracellular activity results both in activity against current drug-resistant strains of HIV-1 and a low potential for systemic toxicities. As a peptide, enfuvirtide also exhibits few interactions with other antiretrovirals and concomitant medications used in HIV disease. Enfuvirtide shows potent antiretroviral activity and significantly improves medical outcomes in highly treatment-experienced patients with HIV-1 infection, but like other antiretrovirals must be given as part of a carefully selected combination regimen to minimise the risk of emergent drug resistance. Despite its subcutaneous route of administration, clinical data indicate that most patients can accept long-term enfuvirtide treatment with little difficulty or impact on daily activities. The only common adverse event associated with enfuvirtide use is injection-site reactions of generally mild-to-moderate severity, which are seldom treatment-limiting.

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C WildT Matthews
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E O FreedR Risser
Jan 1, 1989·Archives of Virology·H R GelderblomG Pauli
Aug 1, 1989·AIDS Research and Human Retroviruses·W R GallaherR C Montelaro
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R L WilleyR D Klausner
Apr 1, 1988·AIDS Research and Human Retroviruses·R BrasseurJ M Ruysschaert
Jan 1, 1988·Archives of Virology·M OzelH R Gelderblom
Jan 1, 1987·AIDS Research and Human Retroviruses·F Gonzalez-ScaranoJ A Hoxie
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·C T WildT J Matthews
Nov 1, 1993·AIDS Research and Human Retroviruses·C WildT Matthews
Sep 15, 1993·Biochemical and Biophysical Research Communications·S JiangA R Neurath
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·D M LambertS R Petteway
Dec 1, 1995·Nature Structural Biology·M LuP S Kim
May 22, 1997·Nature·W WeissenhornD C Wiley
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·K TanM Lu
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·C M CarrP S Kim
Apr 1, 1998·Journal of Cutaneous Pathology·C M MagroB L Schapiro
Jun 18, 1998·Cell·D C Chan, P S Kim
Sep 6, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jacob P LalezariTosca Kinchelow
Oct 25, 2003·Journal of the American Academy of Dermatology·Russell A BallUNKNOWN ISR Substudy Group

❮ Previous
Next ❯

Citations

Jan 25, 2011·European Biophysics Journal : EBJ·Avraham Ashkenazi, Yechiel Shai
Aug 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eugènia NegredoBonaventura Clotet
Feb 16, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Francois RaffiMiklos Salgo
Jun 3, 2005·AIDS Research and Human Retroviruses·Avelin Fobang AghokengMartine Peeters
Mar 21, 2013·The Journal of Antimicrobial Chemotherapy·Francisco Díez-FuertesMichael M Thomson
Jan 5, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paolo LussoVincenzo Pavone
Oct 31, 2007·Antimicrobial Agents and Chemotherapy·Céline DeffrasnesGuy Boivin
Jan 28, 2006·Journal of Virology·Mariko KobayashiIla R Singh
May 2, 2014·Biochimica Et Biophysica Acta·Hussain BadaniWilliam C Wimley
Apr 26, 2006·Expert Opinion on Emerging Drugs·Claude FortinPatrick Yeni
Jun 7, 2005·Expert Opinion on Emerging Drugs·Erik De Clercq
May 26, 2009·Actas dermo-sifiliográficas·M BlanesJ Portilla
Sep 1, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Stephen E SchneiderMaynard Lichty
Feb 22, 2011·The Australasian Journal of Dermatology·Brian J WallaceMargot J Whitfeld
Mar 13, 2014·Chemical Biology & Drug Design·Aussara PanyaPa-Thai Yenchitsomanus
Jul 11, 2006·Antiviral Research·Rudi Pauwels
Jun 28, 2005·The Lancet Infectious Diseases·Evan WoodJulio S G Montaner
Jan 20, 2012·The Journal of General Virology·Marlynne Q NicolAnthony A Nash
Mar 30, 2005·Expert Opinion on Pharmacotherapy·Adriano Lazzarin
Sep 1, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Luciana Santos PessoaAmilcar Tanuri
Jan 21, 2015·Marine Drugs·Hee Kyoung KangYoonkyung Park
Sep 22, 2018·PloS One·Manuela GrimaldiAnna Maria D'Ursi
Sep 5, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Denis M TebitHans-Georg Krausslich
Jul 26, 2005·The Journal of Antimicrobial Chemotherapy·George A Pankey
Apr 24, 2019·Chembiochem : a European Journal of Chemical Biology·Takuya KobayakawaHirokazu Tamamura
Feb 9, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Joanna Smoleń-DzirbaAnd The Cascade Collaboration In EuroCoord
Jun 6, 2019·Beilstein Journal of Nanotechnology·Zaid K AlghrairBahram Ebrahimi
Dec 29, 2018·The Journal of Physical Chemistry. B·Aurélie PerrierAnne Vanet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The New England Journal of Medicine
J Michael Kilby, Joseph J Eron
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
I HerryC Perronne
© 2022 Meta ULC. All rights reserved