Peptide ligands targeting integrin alpha3beta1 in non-small cell lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Derick H LauKit S Lam

Abstract

Lung cancer is one of the most common cancers and is the leading cause of cancer death. We wish to identify peptide ligands for unique cell surface receptors of non-small lung cancer with the hope of developing these ligands as diagnostic and therapeutic agents. Using the method of 'one-bead one-peptide' combinatorial chemistry, a library of random cyclic octapeptides was synthesized on polystyrene beads. This library was used to screen for peptides that promoted attachment of lung adenocarcinoma cells employing a 'cell-growth-on-bead' assay. Consensus peptide sequences of cNGXGXXc were identified. These peptides promoted cell adhesion by targeting integrin alpha3beta1 over-expressed in non-small lung cancer cells. These peptide beads can be applied to capture cancer cells in malignant pleural fluid for purpose of diagnosis of lung cancer.

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Citations

Aug 21, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Wenwu XiaoKit S Lam
Dec 14, 2011·Cancer Metastasis Reviews·Moonmoon DebSamir Kumar Patra
Dec 5, 2013·Chemical Reviews·Bethany Powell Gray, Kathlynn C Brown
Aug 25, 2012·Future Medicinal Chemistry·Áron Roxin, Gang Zheng
Sep 27, 2008·Lab on a Chip·Andrea CarbonaroLydia L Sohn
Sep 20, 2011·Chembiochem : a European Journal of Chemical Biology·Morten MeldalGrith Hagel
May 24, 2016·Advanced Drug Delivery Reviews·Ruiwu LiuKit S Lam
Aug 30, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yan ZouZhiyuan Zhong
Jan 16, 2018·Advanced Healthcare Materials·Jiayu LeongHyunjoon Kong
Sep 21, 2007·Molecular Pharmaceutics·Olulanu H AinaKit S Lam

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