Peptide loading onto recycling HLA-DR molecules occurs in early endosomes

European Journal of Immunology
V Pinet, E O Long

Abstract

Presentation of exogenous antigens to MHC class II-restricted T cells can follow two different processing pathways. The classical pathway requires newly synthesized MHC class II molecules, invariant chain and HLA-DM expression, whereas the alternative pathway is independent of protein synthesis, invariant chain and HLA-DM. In both cases, MHC class II molecules associate with peptides derived from exogenous antigens that have been processed in endocytic compartments. Different endosomal/prelysosomal compartments where peptide/MHC class II complexes and HLA-DM molecules accumulate have been described. We show here that the alternative pathway uses an earlier compartment than the classical pathway. Experiments with chemically cross-linked antigen suggest that recycling MHC class II molecules present rapidly degraded antigens, leading to a rapid immune response to exogenously added influenza virus proteins.

References

Feb 1, 1992·The Journal of Experimental Medicine·D R Karp, E O Long
Jun 1, 1996·Current Opinion in Immunology·A Lanzavecchia

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Citations

Jun 8, 1999·European Journal of Immunology·J Neefjes
Aug 19, 2007·Immunologic Research·Matthew A Fischer, Christopher C Norbury
Jan 16, 2002·Current Opinion in Immunology·Elizabeth M Hiltbold, Paul A Roche
Feb 19, 2000·Current Opinion in Immunology·R BuschE D Mellins
Dec 1, 2010·Immunology and Cell Biology·Ole J B LandsverkOddmund Bakke
Mar 29, 2002·Immunology·John H Robinson, Alexei A Delvig
Mar 16, 2000·The EMBO Journal·S O ArndtH Kropshofer
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Thierry Fumeaux, Jérôme Pugin
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·I ChiuJ L Strominger
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·L SantambrogioL J Stern
Mar 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stewart T ChangDenise E Kirschner
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M van LithJ Neefjes
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael P BelmaresElizabeth D Mellins
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gomathinayagam Sinnathamby, Laurence C Eisenlohr
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laure A Perrin-CoconPatrice N Marche
Aug 31, 2000·The Journal of Biological Chemistry·A BrunetJ Thibodeau
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L Ramachandra, C V Harding
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wentao MiE Sally Ward
Jul 2, 2008·Journal of Leukocyte Biology·Rajeev Mani NepalPaula Bryant
Aug 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ioannis KarakikesNelson Fernandez
Mar 3, 2004·European Journal of Immunology·Katie Brooks, Andrew M Knight
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Valentina RobilaVictor H Engelhard
Aug 26, 2009·Scandinavian Journal of Immunology·O J B LandsverkT F Gregers
Oct 23, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A FortinH M Thérien
Jun 28, 2005·International Journal of Cancer. Journal International Du Cancer·Ingeborg ZehbeMarkus J Maeurer
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S S PathakJ S Blum
Aug 12, 2009·Developmental and Comparative Immunology·Dimitar B IlievJorunn B Jørgensen

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