Peptide mass mapping in bioapatites isolated from animal bones.

Journal of Materials Science. Materials in Medicine
Tereza SmrhovaMonika Supová

Abstract

Bioapatite ceramics produced from biogenic sources provide highly attractive materials for the preparation of artificial replacements since such materials are not only more easily accepted by living organisms, but bioapatite isolated from biowaste such as xenogeneous bones also provides a low-cost material. Nevertheless, the presence of organic compounds in the bioapatite may lead to a deterioration in its quality and may trigger an undesirable immune response. Therefore, procedures which ensure the elimination of organic compounds through bioapatite isolation are being subjected to intense investigation and the presence of remaining organic impurities is being determined through the application of various methods. Since current conclusions concerning the conditions suitable for the elimination of organic compounds remain ambiguous, we used the mass spectrometry-based proteomic approach in order to determine the presence of proteins or peptides in bioapatite samples treated under the most frequently employed conditions, i.e., the alkaline hydrothermal process and calcination at 500 °C. Since we also investigated the presence of proteins or peptides in treated bioapatite particles of differing sizes, we discovered that both calc...Continue Reading

References

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Nov 22, 2011·Molecular & Cellular Proteomics : MCP·Christina LudwigRuedi Aebersold
Apr 16, 2014·Journal of Nanoscience and Nanotechnology·Monika Supová

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