Abstract
Modern molecular targeting provides new opportunities for imaging, diagnosis and treatment of diseases. Small molecular weight peptides have the potential for enhancing targeting of compounds, and they may also have therapeutic effects by themselves. The limiting step for successful molecular targeting is the development of efficient peptide delivery systems. This review will focus on peptides developed by phage display and combinatorial chemistry for the delivery of pharmaceuticals, radioactive compounds and gene expression vectors. Target cell-specific delivery can be improved by peptides that penetrate the cell membrane or alternatively induce receptor-mediated endocytosis. In addition, peptides that contain endosomal escape signals or nuclear localization motifs may help trafficking of therapeutics to appropriate locations inside the cell. Small molecule radiolabelled peptides are the preferred agents for targeting and for diagnostic imaging of various organs as they are easily synthesized, effectively penetrate tissues, and are rapidly cleared from the circulation. Such peptides have been tested in animals and humans in the fields of cancer, cardiology, neurology, inflammation/infection, atherosclerosis and thrombosis.
Citations
Oct 6, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Sun JunQu Shen
Apr 9, 2005·Gene Therapy·K Sandvig, B van Deurs
Jul 17, 2008·Biological Chemistry·Hannu KoistinenUlf-Håkan Stenman
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Mai LinXiankai Sun
Nov 22, 2005·Expert Opinion on Drug Delivery·Mouldy Sioud
Jul 6, 2006·Neoplasia : an International Journal for Oncology Research·Ian R CorbinGang Zheng
Jan 7, 2009·International Journal of Cancer. Journal International Du Cancer·Hendrik WittMichele Bernasconi
Sep 20, 2007·Biopolymers·Peng LiPeter P Roller
May 10, 2011·Chemical Society Reviews·Andrew RazgulinJianghong Rao
Jul 12, 2007·Chemical Communications : Chem Comm·Itzia Cruz-CampaJuan C Noveron
Jul 27, 2006·Technology in Cancer Research & Treatment·Zhaozhong HanDennis E Hallahan
Mar 21, 2017·Chemical Society Reviews·Min GaoLingxin Chen
Apr 6, 2007·Cancer Research·Xiu-Fang WangJiri Neuzil
Dec 23, 2008·Bioconjugate Chemistry·Ming WangMaya Thanou
Jan 17, 2008·Bioconjugate Chemistry·Chen-Chang LeeTheresa M Reineke
Aug 1, 2014·Bioconjugate Chemistry·Svetlana AvvakumovaDavide Prosperi