Peptide Mimetic of BDNF Loop 4 Blocks Behavioral Signs of Morphine Withdrawal Syndrome and Prevents the Increase in ΔFosB Level in the Striatum of Rats.

Bulletin of Experimental Biology and Medicine
L G KolikS B Seredenin

Abstract

Activity of compound GSB-106, a low-molecular mimetic of loop 4 of the brain neurotrophic factor (BDNF), was studied in experimental morphine withdrawal syndrome simulated in outbred rats. Single and subchronic (5 intraperitoneal injections) administration of GSB-106 in a dose of 0.1 mg/kg significantly reduced the total index of morphine withdrawal syndrome by 55.2 and 45.6%, respectively. GSB-106 reduced the severity of some behavioral signs (piloerection, gnashing of teeth, wet-dog shaking, and runaway attempts), but had no effect on mechanical allodynia formed in the rats with dependence. Subchronic treatment with GSB-106 prevented the increase in the content of ΔFosB (product of early response gene) in the striatum induced by morphine withdrawal. The results confirmed the concept on the involvement of neurotrophins, specifically BDNF and its analogs, in the mechanisms associated with the formation of opiate dependence.

References

Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·E J NestlerD W Self
Nov 7, 2009·Methods in Enzymology·James E Noble, Marc J A Bailey
Oct 9, 2012·Science·Ja Wook KooEric J Nestler
Jun 16, 2019·Doklady. Biochemistry and Biophysics·T A GudashevaS B Seredenin

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