Peptide mimics of the CTLA4-binding domain stimulate T-cell proliferation

Nature Biotechnology
T FukumotoK Sugimura

Abstract

Phage library clones selected by a conformational epitope-recognizing and inhibitory monoclonal antibody may display moieties that mimic a receptor/ligand-like three-dimensional structure. This pseudoreceptor/ligand should be able to bind to natural ligand/receptor molecules. We tested this idea using anti-T cell costimulatory molecule antibodies and successfully isolated phage clones with costimulatory effects on T-cell proliferation. This strategy facilitates the designing of regulatory peptide molecules in the absence of precise information about the structure-function relationships in receptor/ligand interactions.

References

Oct 1, 1991·Current Opinion in Biotechnology·G P Smith
Sep 11, 1990·Nucleic Acids Research·S Mizushima, S Nagata
Nov 3, 1989·Biochimica Et Biophysica Acta·G Glaser-WuttkeI Rasched
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A YayonE Katchalski-Katzir
Apr 15, 1994·Biochemical and Biophysical Research Communications·M InobeT Uede
Aug 1, 1995·The Journal of Experimental Medicine·M F Krummel, J P Allison
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·J G GribbenG S Gray
Jun 1, 1996·The Journal of Experimental Medicine·T L WalunasJ A Bluestone
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M MurakamiT Uede

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Citations

Jul 27, 1999·Combinatorial Chemistry & High Throughput Screening·G CesareniG Cestra
Aug 17, 1999·Current Opinion in Structural Biology·R W Roberts, W W Ja
Aug 2, 2007·Biological & Pharmaceutical Bulletin·Takayuki HamasakiKazuhisa Sugimura
Feb 15, 2005·Journal of Biotechnology·Takashi NakamuraKeiichi Kawano
Jan 1, 2012·Pharmaceuticals·Ramachandran Murali, Mark I Greene
Feb 3, 2004·Journal of Receptor and Signal Transduction Research·Michael Szardenings
Nov 8, 2005·Journal of Biochemistry·Takayuki HamasakiKazuhisa Sugimura
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael G AgadjanyanDavid B Weiner

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