Peptide Patterns as Discriminating Biomarkers in Plasma of Patients With Familial Adenomatous Polyposis

Clinical Colorectal Cancer
Lisa AgateaMarco Agostini

Abstract

Familial adenomatous polyposis (FAP) is one of the most important clinical forms of inherited susceptibility to colorectal cancer. So far, no accepted prognostic markers are present to monitor patients with FAP. Consequently, the major problem in managing patients with FAP is the difficulty to predict when the switch between adenoma and malignant carcinoma occurs, leading to the necessity of preventive surgery. Proteomics is one of the most suitable approaches to identify biomarkers, and it is widely used in cancer research. In this investigation, we studied the circulating plasma peptides in samples collected from patients with FAP and compared the obtained results with adenoma, colorectal cancer, and control samples to discover peptides able to distinguish different phenotypes. The peptide fingerprint was obtained by matrix-assisted laser desorption/ionization coupled to time-of-flight mass spectrometry. After statistical analysis, a subset of 45 ionic species was found differently expressed in the 4 groups considered, 12 of them peculiar to patients with FAP. Moreover, 4 ionic species were found significantly changed in the switch between adenoma and malignant carcinoma. Potentially prognostic peptides identified by this stu...Continue Reading

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Citations

Sep 7, 2016·Expert Review of Proteomics·Abdo Alnabulsi, Graeme I Murray
Sep 19, 2017·Nature Reviews. Immunology·Edimara S ReisJohn D Lambris
Dec 5, 2019·International Journal of Tryptophan Research : IJTR·Sara CrottiMarco Agostini

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