Peptide-peptoid hybrids based on (1-11)-parathyroid hormone analogs

Journal of Peptide Science : an Official Publication of the European Peptide Society
A CaporaleE Peggion

Abstract

A series of peptide-peptoid hybrids, containing N-substituted glycines, were synthesized based on the H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) (Har = Homoarginine) as the parent parathyroid hormone (1-11) analog. The compounds were pharmacologically characterized in their agonistic activity at the parathyroid hormone 1 receptor.

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