Peptide receptor radionuclide therapy: an overview

Cancer Biotherapy & Radiopharmaceuticals
Ashutosh DashF F Russ Knapp

Abstract

Peptide receptor radionuclide therapy (PRRT) is a site-directed targeted therapeutic strategy that specifically uses radiolabeled peptides as biological targeting vectors designed to deliver cytotoxic levels of radiation dose to cancer cells, which overexpress specific receptors. Interest in PRRT has steadily grown because of the advantages of targeting cellular receptors in vivo with high sensitivity as well as specificity and treatment at the molecular level. Recent advances in molecular biology have not only stimulated advances in PRRT in a sustainable manner but have also pushed the field significantly forward to several unexplored possibilities. Recent decades have witnessed unprecedented endeavors for developing radiolabeled receptor-binding somatostatin analogs for the treatment of neuroendocrine tumors, which have played an important role in the evolution of PRRT and paved the way for the development of other receptor-targeting peptides. Several peptides targeting a variety of receptors have been identified, demonstrating their potential to catalyze breakthroughs in PRRT. In this review, the authors discuss several of these peptides and their analogs with regard to their applications and potential in radionuclide therap...Continue Reading

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Methods Mentioned

BETA
thermal neutron capture
xenografts
ion-exchange chromatography
phage display
direct

Related Concepts

Analogs & derivatives
Chelating Agents
Biological Evolution
Genetic Vectors
Molecular Biology
Peptides
Radioisotopes
Radionuclide Therapy
Peptide Receptor
Neuroendocrine Tumors

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