Peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE in individuals with neck or mediastinal paraganglioma (PGL)

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
S ZovatoG Paganelli

Abstract

Paragangliomas (PGLs) are neuroendocrine tum-ors that arise embryologically from the neural crest. Sympathetic PGLs can be located in the thoracic-abdominal region while parasympathetic PGLs are mainly situated in the head and neck region. Most PGLs are sporadic, but in 30% of cases they are hereditary (associated with mutations of SDHB, SDHC, SDHD, SDHAF2, SDHA, TMEM, MAX, and VHL); they can be classified into 4 different paraganglioma syndromes: PGL1, PGL2, PGL3, and PGL4. Surgery is the treatment of choice for both sympathetic and parasympathetic PGLs. Other types of treatment include medical agents (such as gemcitabine, cisplatin, or sunitinib) and radiotherapy (external-beam radiotherapy or stereotactic surgery). Surgery and radiotherapy, however, can cause important side effects such as vascular complications and peripheral nerve damage (hypoglossal, recurrent laryngeal, glossopharyngeal, and vagus). Another possible treatment option is the use of peptide receptor radionuclide therapy (PRRT), including PRRT with 177Lu-DOTATATE. We studied 4 patients with hereditary nonmetastatic paraganglioma syndrome type 1 (PGL1), with progressive disease, in whom surgical excision was not possible. They were treated with 177Lu-DOTATATE...Continue Reading

Citations

Sep 28, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Giorgio Treglia, Luca Giovanella
Jan 17, 2012·Endocrine Pathology·Anne-Paule Gimenez-Roqueplo, Arthur S Tischler
Aug 8, 2013·Endocrine-related Cancer·Cristina CapatinaAshley B Grossman
Mar 19, 2014·Current Problems in Cancer·Victoria L Martucci, Karel Pacak
Apr 23, 2013·Head & Neck·Leonie T van HulsteijnEleonora P M Corssmit
Jun 6, 2015·Endocrine-related Cancer·Frédéric CastinettiDavid Taieb
Apr 22, 2015·The American Journal of Cardiology·Victoria L MartucciKarel Pacak
Mar 31, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Ameya D PuranikRichard P Baum
Aug 19, 2016·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Chian A ChangMichael S Hofman
Apr 13, 2017·Endocrine-related Cancer·Anna AngelousiAshley Grossman
Feb 11, 2018·Cell and Tissue Research·Charlotte Lussey-LepoutreJudith Favier
Feb 17, 2018·Cell and Tissue Research·David Taïeb, Karel Pacak
Feb 7, 2019·EJNMMI Research·Madhav Prasad YadavChandrasekhar Bal
Jul 3, 2019·Journal of Clinical Medicine·Agnieszka Kolasinska-ĆwikłaAndrzej Januszewicz
Jan 23, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Andreas G MoraitisKarel Pacak
Aug 31, 2019·Current Treatment Options in Oncology·Grace Kong, Rodney J Hicks
Dec 13, 2018·Frontiers in Endocrinology·Rami AlrezkKarel Pacak
Apr 13, 2019·The Journal of Clinical Endocrinology and Metabolism·Grace KongRodney J Hicks
Jun 13, 2017·The Journal of Clinical Endocrinology and Metabolism·Grace KongRodney J Hicks
Jun 25, 2019·Nuclear Medicine and Molecular Imaging·Katherine I WolfKarel Pacak
Nov 18, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Leilani B Mercado-AsisDavid Taïeb
Oct 24, 2020·Current Opinion in Oncology·Christiane Jungels, Ioannis Karfis
Dec 10, 2020·Clinical Endocrinology·Simon J RyderDavid A Pattison
Apr 16, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ingo JanssenKarel Pacak
Feb 4, 2021·Journal of Medicinal Chemistry·Rajendra P BandariCharles J Smith
Jan 7, 2021·Current Urology Reports·Hiren V PatelEric A Singer
Nov 14, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ingo JanssenKarel Pacak
Jun 20, 2021·Endocrine Reviews·Svenja NöltingKarel Pacak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
A-P Gimenez-RoqueploMercedes Robledo
The Journal of Clinical Endocrinology and Metabolism
José GaalWinand N M Dinjens
Journal of the American College of Surgeons
Linwah YipDouglas B Evans
© 2021 Meta ULC. All rights reserved