PMID: 9434904Jan 22, 1998Paper

Peptide recognition by PTB and PDZ domains

Current Opinion in Structural Biology
D Cowburn

Abstract

Protein tyrosine binding (PTB) and 'post synaptic density disc-large zo-1' (PDZ) domains bind to short peptidic ligands by augmentation of one of the domain's beta sheets and other recognition mechanisms. The two domain classes have a superficial resemblance to each other, even though no sequential homology exists. The structural bases of the interactions are well understood for the few domains now experimentally determined, and ligand-target pairs can probably be identified in favorable cases by analogy with the known domains. For both PTB and PDZ classes, functional activities are still not fully defined: it is possible that these domain classes, along with pleckstrin homology domains, have multiple roles.

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Citations

Jan 4, 2003·Chembiochem : a European Journal of Chemical Biology·Sachdev S SidhuKurt Deshayes
Jun 4, 1999·Progress in Biophysics and Molecular Biology·Z Songyang
Dec 23, 1999·Current Opinion in Structural Biology·J D Forman-Kay, T Pawson
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Feb 13, 2021·Peptide Science·Haley I MerrittParamjit S Arora

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