PMID: 8988395Jan 1, 1996Paper

Peptide selection for presentation by HLA class I: a role for the human transporter associated with antigen processing?

Immunologic Research
P M van Endert

Abstract

Peptide epitopes presented by HLA class I are supplied by an elaborate system of antigen processing which subjects candidate epitopes to a process of selection according to little-understood rules. Transport of peptides from the cytosol into the endoplasmic reticulum by the TAP (transporter associated with antigen processing) complex is likely to play an important role in peptide selection for presentation. The recent development of an assay measuring substrate binding to the TAP complex has led to the identification of the major structural properties of peptides selected by the human transporter. Human TAP favors transport of peptides with structural features common to HLA class I ligands. However, TAP dislikes peptide ligands preferred by some HLA class I alleles, which may therefore frequently rely on alternative sources of peptide ligands.

References

Dec 1, 1995·The Journal of Experimental Medicine·P M van EndertJ F Bach
Aug 1, 1995·European Journal of Immunology·R ObstG J Hämmerling
Apr 1, 1995·European Journal of Immunology·J NeefjesF Momburg
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·M J AndrolewiczP Cresswell
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·A Hill, H Ploegh
Jan 1, 1995·Immunogenetics·H G RammenseeS Stevanoviíc
Nov 1, 1994·The Journal of Experimental Medicine·J RoelseJ Neefjes
Dec 1, 1994·The Journal of Experimental Medicine·H L SnyderJ R Bennink
May 1, 1994·The Journal of Experimental Medicine·F MomburgJ J Neefjes

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Citations

Nov 16, 2004·Methods : a Companion to Methods in Enzymology·Nikolai Petrovsky, Vladimir Brusic
Apr 15, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Benjamin J UmlaufKathlynn C Brown
Jul 9, 2004·Nature·Marianne Boes, Hidde L Ploegh
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elke FiratGabriele Niedermann
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elke FiratGabriele Niedermann

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