Peptide self-aggregation and peptide complementarity as bases for the evolution of peptide receptors: a review

Journal of Molecular Recognition : JMR
R S Root-Bernstein

Abstract

This paper reviews the three major theories of peptide receptor evolution: (1) Dwyer's theory that peptide receptors evolved from self-aggregating peptides; (2) Root-Bernstein's theory that peptide receptors evolved from functionally and structurally complementary peptides; and (3) Blalock's theory that receptors evolved from hydropathically complementary sequences encoded in the antisense strand of the DNA encoding each peptide. The evidence to date suggests that the co-yevolution of peptides and their receptors is strongly constrained by one or more of these physicochemically based mechanisms, which argues against a random or frozen accident' model. The data also suggest that structure and function are integrally related from the earliest steps of receptor-ligand evolution so that peptide functionality is non-random and highly conserved in its origin. The result is a molecular paleontology' that reveals the evolutionary constraints that shaped the interaction of structure and function.

References

Feb 28, 1975·Annals of the New York Academy of Sciences·A GlobersonD Friedman
Apr 29, 1975·Biochimica Et Biophysica Acta·P Anzenbacher, V Kalous
Jan 1, 1979·Annual Review of Biochemistry·E Breslow
Apr 1, 1979·Acta diabetologica latina·V Kalous, P Anzenbacher
Jan 1, 1992·Bio Systems·I Z Siemion, P Stefanowicz
Sep 1, 1992·Gastroenterology·J E McGuigan, M Campbell-Thompson
Apr 24, 1992·Journal of Chromatography·I Chaiken
Oct 1, 1991·Journal of Molecular Evolution·K J Fryxell, E M Meyerowitz
Dec 1, 1990·Brain Research Bulletin·Y TakeuchiJ C Shih
Jan 1, 1991·Current Topics in Pathology. Ergebnisse Der Pathologie·R D Hesch
Jan 1, 1990·Comparative Biochemistry and Physiology. A, Comparative Physiology·C Schwabe
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·F X LuI Chaiken
Jul 1, 1990·Peptides·J M KellyC I Johnston
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B L Clarke, J E Blalock
Feb 1, 1990·Brain : a Journal of Neurology·N R Graff-RadfordJ P Brandt
Dec 31, 1987·Biochemical and Biophysical Research Communications·U B Rasmussen, R D Hesch
Jan 1, 1989·Viral Immunology·K L Bost, J E Blalock
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A Goldstein, D L Brutlag
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K L BostJ E Blalock
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·T S EltonJ E Blalock
Apr 1, 1987·Brain Research Bulletin·R S Root-Bernstein
Dec 1, 1968·Journal of Molecular Biology·F H Crick
May 31, 1984·Biochemical and Biophysical Research Communications·J E Blalock, E M Smith
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S H LauF J Kézdy
Feb 21, 1982·Journal of Theoretical Biology·R S Root-Bernstein
Feb 21, 1982·Journal of Theoretical Biology·R S Root-Bernstein
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Dec 1, 1995·Nature Medicine·J Ruf, P Carayon

❮ Previous
Next ❯

Citations

Jun 26, 2009·Cellular and Molecular Life Sciences : CMLS·Robert Root-Bernstein, Jessica Vonck
May 29, 2014·International Journal of Molecular Sciences·Nikola ŠtambukMario Gabričević
Jan 13, 2011·Progress in Biophysics and Molecular Biology·Gábor Maksay
Mar 21, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Axel HundingRobert Root-Bernstein
Aug 8, 2014·Frontiers in Endocrinology·Robert Root-BernsteinPatrick F Dillon
Sep 17, 2016·Transcription·Robert Root-BernsteinZachary F Burton
Jun 24, 2020·Journal of Molecular Recognition : JMR·Guy W DayhoffVladimir N Uversky
May 1, 2019·International Journal of Molecular Sciences·Nikola ŠtambukMario Gabričević
Aug 23, 2020·IScience·Aditya Yashwant SarodeBhaskar Saha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.