Peptide-targeted Nanoglobular Gd-DOTA monoamide conjugates for magnetic resonance cancer molecular imaging.

Biomacromolecules
Mingqian TanZheng-Rong Lu

Abstract

Effective imaging of a cancer molecular biomarker is critical for accurate cancer diagnosis and prognosis. CLT1 peptide was observed to specifically bind to the fibrin-fibronectin complexes presented in tumor extracellular matrix. In this study, we synthesized and evaluated CLT1 peptide-targeted nanoglobular Gd-DOTA monoamide conjugates for magnetic resonance (MR) imaging of the fibrin-fibronectin complexes in tumor. The targeted nanoglobular contrast agents were prepared by conjugating peptide CLT1 to G2 and G3 nanoglobule (lysine dendrimers with a cubic silsesquioxane core) Gd-DOTA monoamide conjugates via click chemistry. The T(1) relaxivities of peptide-targeted G2 and G3 nanoglobules were 7.92 and 8.20 mM(-1) s(-1) at 3T, respectively. Approximately 2 peptides and 25 Gd-DOTA chelates were conjugated onto the surface of 32 amine groups of G2 nanoglobule, and 3 peptides and 43 Gd-DOTA chelates onto the surface of 64 amine groups of G3 nanoglobule. The peptide-targeted nanoglobular contrast agents showed greater contrast enhancement than the corresponding nontargeted agents in tumor at a dose of 0.03 mmol-Gd/kg in female athymic mice bearing MDA-MB-231 human breast carcinoma xenografts. The targeted MRI contrast agents have a...Continue Reading

References

Jun 1, 1997·Virchows Archiv : an International Journal of Pathology·N Wernert
Jul 19, 2002·Journal of Cellular Physiology·Serenella M PupaElda Tagliabue
Sep 17, 2004·Chemistry : a European Journal·Luca FrullanoJoop A Peters
Aug 2, 2005·Molecular Pharmaceutics·Vincent J VendittoMartin W Brechbiel
Dec 29, 2005·International Journal of Cancer. Journal International Du Cancer·Manuela KasparDario Neri
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jan PilchErkki Ruoslahti
Jun 10, 2008·Molecular Pharmaceutics·C Andrew BoswellMartin W Brechbiel
Oct 1, 2008·Angewandte Chemie·Eric J WernerKenneth N Raymond

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Citations

Jul 19, 2013·Biomaterials·Zhuxian ZhouZheng-Rong Lu
Sep 11, 2012·Investigative Radiology·Ritika UppalPeter Caravan
May 22, 2013·BioMed Research International·Norma Y Hernández-PedroJulio Sotelo
Oct 19, 2013·Pharmacology & Therapeutics·Lian NarunskyMichal Neeman
Jan 11, 2013·Organic & Biomolecular Chemistry·Sebastian FabritzHarald Kolmar
Sep 30, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Jonathan MartinelliRamon Vilar
May 27, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mathieu ArseneaultJean-François Morin
Dec 8, 2015·Advanced Drug Delivery Reviews·Heena Kumra, Dieter P Reinhardt
May 14, 2014·Advanced Drug Delivery Reviews·Mathumai KanapathipillaiDonald E Ingber
Aug 17, 2010·Neuroimaging Clinics of North America·Ketan B GhaghadaSrinivasan Mukundan
Oct 11, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zhuxian Zhou, Zheng-Rong Lu
Nov 4, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Sumita RahaGayle Woloschak
Apr 16, 2015·BioMed Research International·Zhiming LiXiaoming Yang
Apr 24, 2012·Biomaterials·Yongjun Liu, Na Zhang
Oct 22, 2013·Biomaterials·Chang-Tong YangEdward G Robins
Aug 9, 2016·Advanced Drug Delivery Reviews·Zhuxian Zhou, Zheng-Rong Lu
Mar 3, 2011·Seminars in Oncology·Alexei Bogdanov, Mary L Mazzanti
Oct 7, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Helene StrauchHermann A Mayer
Oct 16, 2016·Magnetic Resonance Imaging Clinics of North America·Arnav MehtaSrinivasan Mukundan
Oct 18, 2016·Topics in Magnetic Resonance Imaging : TMRI·Sudath Hapuarachchige, Dmitri Artemov
Nov 22, 2016·Human Vaccines & Immunotherapeutics·Yimei JiaMichael J McCluskie
Sep 21, 2017·Chemical Society Reviews·Wing-Fu LaiWing-Tak Wong
Jun 20, 2018·Nanoscale·Elisabetta AvitabileLucia Gemma Delogu
Sep 27, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Amerigo PagotoEnzo Terreno
Jul 18, 2018·Chemistry : a European Journal·Pauline DésogèrePeter Caravan
Aug 13, 2015·Nature Communications·Zhuxian ZhouZheng-Rong Lu
Jun 30, 2019·Current Medicinal Chemistry·Mehdi RajabiShaker A Mousa
Oct 20, 2020·Investigative Radiology·Sergey ShuvaevPeter Caravan
Oct 3, 2018·Current Opinion in Biomedical Engineering·Zheng-Rong Lu

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